Altered brain activities in suicidal subjects have been reported in a number of neuroimaging studies. However, the activity aberrances were inconsistent in previous investigations. Thus, we aimed to address activity abnormalities in suicidal individuals. Databases were searched to perform a meta-analysis of whole-brain functional MRI studies of suicidal individuals through January 14, 2020. Meta-analyses were conducted using Seed-based d Mapping software. Based on a meta-analysis of 17 studies comprising 381 suicidal individuals and 642 controls, we mainly found that increased activity in the bilateral superior temporal gyrus, left middle temporal gyrus, and bilateral middle occipital gyrus, along with decreased activity in the right putamen and left insula, were detected in suicidal individuals compared with nonsuicidal subjects. To reduce methodological heterogeneity between the included studies, subanalyses of behavioral domains were conducted, and the right superior temporal gyrus was found to increase in all subanalyses of domains. In subanalyses of suicidal attempters and ideators, suicide attempters displayed hyperactivation in the bilateral superior temporal gyrus and left middle temporal gyrus and blunted responses in the left insula relative to controls. Suicidal ideators demonstrated elevated activation in the right middle occipital gyrus and reduced activity in the right putamen relative to controls. The bilateral superior temporal gyrus was the most robust finding, replicable in all data sets in the jackknife sensitive analysis. Moreover, increased activity in the right superior temporal gyrus, left middle temporal gyrus, and right middle occipital gyrus was found to be involved with higher suicide ideation scores. This study revealed several brain regions associated with suicidality. These findings may contribute to our understanding of the pathophysiology of suicide and have important implications for suicide prevention and interventions.

许多神经影像学研究报告了自杀受试者的大脑活动改变。然而，在之前的调查中，活动异常并不一致。因此，我们旨在解决自杀个体的活动异常。搜索数据库以对截至 2020 年 1 月 14 日的自杀个体的全脑功能 MRI 研究进行荟萃分析。使用基于种子的 d Mapping 软件进行荟萃分析。基于对包括 381 名自杀者和 642 名对照组的 17 项研究的荟萃分析，我们主要发现双侧颞上回、左侧颞中回和双侧枕中回的活动增加，而右侧壳核和与非自杀受试者相比，在自杀个体中检测到左脑岛。为了减少纳入研究之间的方法异质性，对行为领域进行了子分析，发现右侧颞上回在所有领域的子分析中都有所增加。在对自杀未遂者和想法者的子分析中，与对照组相比，自杀未遂者的双侧颞上回和左侧颞中回表现出过度活跃，而左侧岛叶的反应迟钝。与对照组相比，有自杀倾向的人表现出右侧枕中回的激活升高，而右侧壳核的活动降低。双侧颞上回是最有力的发现，可在折刀敏感分析的所有数据集中复制。此外，右侧颞上回、左侧颞中回的活动增加，右侧枕中回被发现与较高的自杀意念评分有关。这项研究揭示了与自杀相关的几个大脑区域。这些发现可能有助于我们了解自杀的病理生理学，并对自杀预防和干预具有重要意义。