Introduction Solid organ transplant recipients seem to be more susceptible to severe COVID-19. Objectives Our study aimed to assess the clinical outcomes of COVID-19 in the kidney (KTR) and liver transplant recipients (LTR). Patients and methods In this single-center study, medical records of kidney and liver transplant recipients with PCR-confirmed COVID-19, admitted to the hospital between 9th of November 2020 and 26th of February 2021 were retrospectively reviewed. Results Overall, forty-one patients, including thirty-two kidney transplant (78%), one kidney-pancreas (2.4%) and eight liver transplant recipients (19.5%) were included. Seven patients (17%) experienced COVID-19 in the first month after transplantation. Among KTRs 72% were male and the median patient's age was 54 years (IQR 47-62). During a median of 12 days (IQR 8-18) of hospital stay, 72.7% of KTRs experienced acute kidney injury, 45.5% developed acute respiratory distress syndrome (ARDS) and 30.3% died. Baseline estimated glomerular filtration rate, a respiratory rate on admission and diabetes mellitus constituted independent risk factors for in-hospital mortality in KTRs. LTRs experienced a relatively mild COVID-19, only two patients (25%) required oxygen supplementation and one patient (12.5%) died from severe ARDS. Conclusion In sum, hospitalized kidney transplant recipients with COVID-19 are at high risk of acute kidney injury, ARDS and death.

中文翻译：

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COVID-19 在住院肾和肝移植受者中的结果——单中心经验。

简介 实体器官移植受者似乎更容易感染严重的 COVID-19。目的 我们的研究旨在评估 COVID-19 在肾脏 (KTR) 和肝移植受者 (LTR) 中的临床结果。患者和方法 在这项单中心研究中，回顾性审查了 2020 年 11 月 9 日至 2021 年 2 月 26 日期间住院的经 PCR 确认的 COVID-19 肾和肝移植受者的医疗记录。结果共纳入41例患者，其中肾移植32例（78%），肾胰1例（2.4%），肝移植受者8例（19.5%）。七名患者（17%）在移植后的第一个月出现了 COVID-19。在 KTR 中，72% 为男性，患者的中位年龄为 54 岁（IQR 47-62）。在中位 12 天 (IQR 8-18) 的住院期间，72.7% 的 KTR 出现急性肾损伤，45.5% 出现急性呼吸窘迫综合征 (ARDS)，30.3% 死亡。基线估计的肾小球滤过率、入院时的呼吸频率和糖尿病构成 KTR 院内死亡率的独立危险因素。LTR 经历了相对温和的 COVID-19，只有两名患者 (25%) 需要补充氧气，一名患者 (12.5%) 死于严重的 ARDS。结论 总之，COVID-19 住院肾移植受者发生急性肾损伤、ARDS 和死亡的风险较高。入院时的呼吸频率和糖尿病构成 KTR 院内死亡率的独立危险因素。LTR 经历了相对温和的 COVID-19，只有两名患者 (25%) 需要补充氧气，一名患者 (12.5%) 死于严重的 ARDS。结论 总之，COVID-19 住院肾移植受者发生急性肾损伤、ARDS 和死亡的风险较高。入院时的呼吸频率和糖尿病构成 KTR 院内死亡率的独立危险因素。LTR 经历了相对温和的 COVID-19，只有两名患者 (25%) 需要补充氧气，一名患者 (12.5%) 死于严重的 ARDS。结论 总之，COVID-19 住院肾移植受者发生急性肾损伤、ARDS 和死亡的风险较高。