Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition that can affect multiple organs. IgG4-RD may show a variety of initial symptoms. In the oral mucosa, lesions present as inflammatory fibrosis with a large number of IgG4-positive plasma cells. Evaluating treatment is a well-known problem in IgG4-RD due to the absence of an established assessment system. There are difficulties in defining the severity of the disease, which is why treatment is primarily based on its clinical manifestations. We present a case report of localized IgG4-RD with ulcerative and proliferative manifestations on the tongue, which clinically mimicked oral squamous cell carcinoma. A tumor-like lesion on the tongue can indicate something else other than the malignant or reactive changes commonly found in the oral mucosa. Multiple differential diagnoses of these atypical oral lesions, including localized IgG4-RD, should be considered.

中文翻译：

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舌头上出现的局部 IgG4 相关疾病：病例报告。

免疫球蛋白 G4 相关疾病 (IgG4-RD) 是一种免疫介导的纤维炎症性疾病，可影响多个器官。IgG4-RD 可能表现出多种初始症状。在口腔黏膜中，病变表现为炎症性纤维化，伴有大量 IgG4 阳性浆细胞。由于缺乏既定的评估系统，评估治疗是 IgG4-RD 中的一个众所周知的问题。很难确定疾病的严重程度，这就是为什么治疗主要基于其临床表现。我们报告了一个局部 IgG4-RD 在舌上出现溃疡和增殖表现的病例报告，临床上类似于口腔鳞状细胞癌。舌头上的肿瘤样病变可能表明除了口腔粘膜中常见的恶性或反应性变化之外的其他东西。