BACKGROUND Open-angle glaucoma (OAG) and Alzheimer's disease (AD) are two age-related neurodegenerative diseases of significant public health importance. Epidemiological studies have indicated that there might be an association between the disorders. METHODS Predictors of AD, including mixed and unspecified dementia, were analysed in a cohort of 712 residents aged 65-74 years, examined in a population survey in the rural district of Tierp, Sweden, from 1984 to 1986. To expand the sample size, 821 people were recruited by means of glaucoma case records established at the Eye Department in Tierp from 1978 to 2007. In this way, the cohort comprised 1,533 people, representing more than 21,000 person-years at risk. Medical records were reviewed to identify subjects diagnosed with dementia. Those with a follow-up duration shorter than 2 years were excluded. RESULTS By the conclusion of the study, in August 2020, 307 subjects had received a diagnosis of AD, including mixed and unspecified dementia. Of these cases, 55 were affected with definite OAG at baseline. Higher age and ischemic heart disease were the only predictors of AD identified. In multivariate analysis, adjusting for age, participation in the population survey and competing events, no association was found between OAG and AD (hazard ratio 1.08; 95% confidence interval: 0.80-1.47). CONCLUSION In this long-term follow-up study of subjects aged 65-74 years old in Sweden, OAG was not associated with AD.

中文翻译：

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瑞典开角型青光眼与阿尔茨海默病之间的关联：一项基于人群的长期随访研究。

背景技术开角型青光眼(OAG)和阿尔茨海默病(AD)是两种具有重大公共卫生重要性的与年龄相关的神经退行性疾病。流行病学研究表明，这些疾病之间可能存在关联。方法 在 1984 年至 1986 年在瑞典蒂尔普农村地区进行的一项人口调查中，对 712 名 65-74 岁的居民进行了分析，分析了 AD 的预测因素，包括混合性和未指明的痴呆症。为了扩大样本量，通过 1978 年至 2007 年在蒂尔普眼科建立的青光眼病例记录招募了 821 人。这样，该队列由 1,533 人组成，代表超过 21,000 人年的风险。审查医疗记录以确定被诊断患有痴呆症的受试者。排除随访时间短于 2 年的患者。结果截至研究结束时，2020 年 8 月，307 名受试者被诊断为 AD，包括混合性和未指明的痴呆症。在这些病例中，55 例在基线时受到明确的 OAG 影响。高龄和缺血性心脏病是唯一确定的 AD 预测因素。在对年龄、参与人口调查和竞争事件进行调整的多变量分析中，未发现 OAG 和 AD 之间存在关联（风险比 1.08；95% 置信区间：0.80-1.47）。结论 在这项针对瑞典 65-74 岁受试者的长期随访研究中，OAG 与 AD 无关。55 人在基线时受到明确的 OAG 影响。高龄和缺血性心脏病是唯一确定的 AD 预测因素。在对年龄、参与人口调查和竞争事件进行调整的多变量分析中，未发现 OAG 和 AD 之间存在关联（风险比 1.08；95% 置信区间：0.80-1.47）。结论 在这项针对瑞典 65-74 岁受试者的长期随访研究中，OAG 与 AD 无关。55 人在基线时受到明确的 OAG 影响。高龄和缺血性心脏病是唯一确定的 AD 预测因素。在对年龄、参与人口调查和竞争事件进行调整的多变量分析中，未发现 OAG 和 AD 之间存在关联（风险比 1.08；95% 置信区间：0.80-1.47）。结论 在这项针对瑞典 65-74 岁受试者的长期随访研究中，OAG 与 AD 无关。