The tumor microenvironment is considered one of the main players in tumor development and progression. The tumor microenvironment composed of a large number of extracellular matrix proteins is very complex. The continuous accumulation of extracellular matrix proteins has been shown to play a key role in tumor bioregulation, including proliferation, invasion, matrix remodeling. If these processes can be detected early, and effective interventions can be given in time, the progression of the tumor may be delayed. Therefore, there is an urgent need to explore new biomarkers and therapeutic targets. In recent years, studies have shown that periostin (POSTN) may regulate multiple biological behaviors of tumor cells. Here we review the updated progress on the role of POSTN in pathologic pathways of tumor development and progression to explore whether POSTN is a potential therapeutic target.

中文翻译：

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POSTN在各种肿瘤中的研究现状及前景。

肿瘤微环境被认为是肿瘤发展和进展的主要参与者之一。由大量细胞外基质蛋白组成的肿瘤微环境非常复杂。细胞外基质蛋白的持续积累已被证明在肿瘤生物调节中发挥关键作用，包括增殖、侵袭、基质重塑。如果能及早发现这些过程，及时给予有效干预，可能会延缓肿瘤的进展。因此，迫切需要探索新的生物标志物和治疗靶点。近年来，研究表明骨膜素（POSTN）可能调节肿瘤细胞的多种生物学行为。