EphB4 is a membrane tyrosine kinase receptor involved in a number of physiologic and pathologic conditions, cancer being the one drawing the highest attention. In mammalians, EphB4 regulates blood vessel growth and differentiation. EphB4 also mediates a number of cancer promoting effects including angiogenesis, invasion, and metastasis. Its effects have been linked to both EphrinB2-dependent and to EphrinB2-independent mechanisms. In spite of its emerging role in physiology and disease, the regulation of EphB4 cellular expression has been poorly described until recently. The present mini-review summarizes the latest findings on EphB4 regulation at the transcriptional and post-transcriptional level and discusses the biologic implications of such novel findings. Perspective on the scenarios opened by such findings and the open questions in EphB4 research is also provided.

中文翻译：

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生理学和癌症疾病中 EphB4 表达的转录和翻译后控制机制。

EphB4 是一种膜酪氨酸激酶受体，参与多种生理和病理状况，癌症是最受关注的一种。在哺乳动物中，EphB4 调节血管生长和分化。EphB4 还介导许多癌症促进作用，包括血管生成、侵袭和转移。其作用与依赖 EphrinB2 和不依赖 EphrinB2 的机制有关。尽管 EphB4 细胞表达的调节在生理学和疾病中的作用越来越突出，但直到最近才被描述得很差。本小型综述总结了转录和转录后水平上 EphB4 调控的最新发现，并讨论了这些新发现的生物学意义。