Polycystic ovarian syndrome (PCOS) is a heterogeneous, persistent endocrine disease that is generally identified in 6-10% of women of reproductive age. Intriguingly, about 55-65% of patients with PCOS display insulin resistance (IR), which can be related to their body weight, ethnicity, or age. Discovering the root cause of PCOS is of particular concern due to IR and abnormal androgen secretion, and continuous attempts have been made to define the complex pathogenic network underlying the syndrome. In addition, PCOS reflects connections between various proteins, genes, and epigenetics affected by environmental influences. Genetic factors such as mutation, epigenetics, and/or expression in noncoding RNAs, particularly miRNA222, play an important role in PCOS pathophysiology and cannot be neglected. Metformin has been used traditionally as a pillar of PCOS treatment, but even effective insulin sensitization therapy can contribute to side effects that reduce patient adherence and limit treatment effectiveness. Therefore, many of the PCOS characteristics can be taken into account for the impact on hyperinsulinemic ovaries which is important in order to develop treatment strategies. Thus our primary objective is to research the therapeutic efficacy of vitamin D in the suppression of miR222 and, secondary to miR222, mediated molecular pathways involving insulin resistance and metabolic defects, which influence ovarian activity, anovula-tion, and finally infertility.

中文翻译：

---

维生素 D 介导的多囊卵巢综合征 miRNA222 相关代谢缺陷抑制治疗潜力的批判性综述。

多囊卵巢综合征 (PCOS) 是一种异质性、持续性内分泌疾病，通常在 6-10% 的育龄妇女中发现。有趣的是，大约 55-65% 的 PCOS 患者表现出胰岛素抵抗 (IR)，这可能与他们的体重、种族或年龄有关。由于 IR 和异常的雄激素分泌，发现 PCOS 的根本原因尤其令人担忧，并且不断尝试确定该综合征背后的复杂致病网络。此外，PCOS 反映了受环境影响影响的各种蛋白质、基因和表观遗传学之间的联系。遗传因素，如突变、表观遗传学和/或非编码 RNA，特别是 miRNA222 中的表达，在 PCOS 病理生理学中起重要作用，不容忽视。二甲双胍传统上被用作 PCOS 治疗的支柱，但即使是有效的胰岛素增敏疗法也会导致副作用，从而降低患者的依从性并限制治疗效果。因此，许多 PCOS 特征可以考虑到对高胰岛素卵巢的影响，这对于制定治疗策略很重要。因此，我们的主要目标是研究维生素 D 在抑制 miR222 以及继 miR222 介导的涉及胰岛素抵抗和代谢缺陷的分子途径中的治疗效果，这些途径影响卵巢活动、无排卵和最终不孕。许多 PCOS 特征可以考虑到对高胰岛素卵巢的影响，这对于制定治疗策略很重要。因此，我们的主要目标是研究维生素 D 在抑制 miR222 以及继 miR222 介导的涉及胰岛素抵抗和代谢缺陷的分子途径中的治疗效果，这些途径影响卵巢活动、无排卵和最终不孕。许多 PCOS 特征可以考虑到对高胰岛素卵巢的影响，这对于制定治疗策略很重要。因此，我们的主要目标是研究维生素 D 在抑制 miR222 以及继 miR222 介导的涉及胰岛素抵抗和代谢缺陷的分子途径中的治疗效果，这些途径影响卵巢活动、无排卵和最终不孕。