In this era of technology, neurological disorders are the most prevalent disorders in growing population. Alzheimer's and Parkinson's diseases are the most common neurological disorders which are manifested by any abnormality in the structure and functions of neurons present in brain and spinal cord. Exposure to environmental pollution is a serious issue which is associated with high morbidity and mortality rate in the worldwide. Air pollutants are the major contributors to induce the inflammation in lungs and brain which ultimately impairs the normal functioning of CNS. Air pollution persuades CNS pathology by inducing the oxidative stress, activation of microglial cells, neuroinflammation and alteration in permeability of blood brain barrier. Similarly, exposure of heavy metals also exhibits the major and long-lasting effects on brain and causes cognitive dysfunction. Likewise, pesticides have also major influence on the etiology of neurological disorders. Pesticides such as paraquat and rotenone are involved in the pathogenesis of Parkinson's disease. Treatment strategy for environmental pollutants-induced neurological disorders is a challenging task because conventional therapeutics are effective but do not have optimum therapeutic efficacy against such type of disorders. This article addresses how the environmental pollutants are involved in the pathogenesis of neurological disorders and treatment strategies to reduce the occurrence of neurological disorders.

中文翻译：

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环境污染物的暴露和神经系统疾病的发展。

在这个技术时代，神经系统疾病是人口增长中最普遍的疾病。阿尔茨海默病和帕金森病是最常见的神经系统疾病，表现为大脑和脊髓中存在的神经元结构和功能的任何异常。暴露于环境污染是一个严重的问题，在世界范围内与高发病率和死亡率有关。空气污染物是诱发肺部和大脑炎症的主要因素，最终损害中枢神经系统的正常功能。空气污染通过诱导氧化应激、小胶质细胞活化、神经炎症和血脑屏障通透性改变来说服 CNS 病理学。相似地，重金属暴露对大脑也表现出主要和持久的影响，并导致认知功能障碍。同样，农药对神经系统疾病的病因也有重大影响。百草枯和鱼藤酮等农药与帕金森病的发病机制有关。环境污染物引起的神经系统疾病的治疗策略是一项具有挑战性的任务，因为常规疗法是有效的，但对此类疾病没有最佳治疗效果。本文探讨了环境污染物如何参与神经系统疾病的发病机制以及减少神经系统疾病发生的治疗策略。百草枯和鱼藤酮等农药与帕金森病的发病机制有关。环境污染物引起的神经系统疾病的治疗策略是一项具有挑战性的任务，因为常规疗法是有效的，但对此类疾病没有最佳治疗效果。本文探讨了环境污染物如何参与神经系统疾病的发病机制以及减少神经系统疾病发生的治疗策略。百草枯和鱼藤酮等农药与帕金森病的发病机制有关。环境污染物引起的神经系统疾病的治疗策略是一项具有挑战性的任务，因为常规疗法是有效的，但对此类疾病没有最佳治疗效果。本文探讨了环境污染物如何参与神经系统疾病的发病机制以及减少神经系统疾病发生的治疗策略。