Although the ERCC2 gene rs13181 polymorphism is involved in the pancreatic cancer pathogenic mechanism, there is no consistent finding. This meta-analysis aimed to determine the association between ERCC2 rs13181 polymorphism and pancreatic cancer. Related articles were searched against the PubMed database in a retrospective way. Additionally, the combined odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were calculated using the random- or fixed-effects model. Altogether, seven articles regarding ERCC2 gene rs13181 polymorphism were enrolled. The combined ORs regarding the relationship of ERCC2 rs13181 polymorphism with pancreatic cancer incidence showed significant differences in each genetic model (C vs. A: OR = 1.14, 95% CI = 1.04-1.26; CC vs. AA: OR = 1.53, 95% CI = 1.24-1.90; AC vs. AA: OR = 1.06, 95% CI 0.92-1.22; recessive model: OR = 1.50, 95% CI = 1.22-1.84; dominant model: OR = 1.16, 95% CI = 1.02-1.32). Additionally, we performed subgroup analysis stratified by race, which revealed that ERCC2 rs13181 polymorphism increased the risk of pancreatic cancer in Asian populations. This work suggests that the ERCC2 gene rs13181 polymorphism is related to pancreatic cancer risk in Asians.

中文翻译：

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ERCC2 rs13181 多态性与胰腺癌易感性的关联研究。

虽然ERCC2基因rs13181多态性参与了胰腺癌的发病机制，但没有一致的发现。这项荟萃分析旨在确定 ERCC2 rs13181 多态性与胰腺癌之间的关联。以回顾性方式在 PubMed 数据库中搜索相关文章。此外，使用随机或固定效应模型计算组合优势比 (OR) 和相应的 95% 置信区间 (CI)。共收录 7 篇关于 ERCC2 基因 rs13181 多态性的文章。ERCC2 rs13181 多态性与胰腺癌发病率关系的综合 OR 在每种遗传模型中显示出显着差异（C vs. A：OR = 1.14, 95% CI = 1.04-1.26；CC vs. AA：OR = 1.53, 95% CI = 1.24-1.90；AC 与 AA：OR = 1.06，95% CI 0.92-1.22；隐性模型：OR = 1.50，95% CI = 1.22-1.84；主导模型：OR = 1.16，95% CI = 1.02-1.32）。此外，我们进行了按种族分层的亚组分析，结果显示 ERCC2 rs13181 多态性增加了亚洲人群患胰腺癌的风险。这项工作表明 ERCC2 基因 rs13181 多态性与亚洲人患胰腺癌的风险有关。