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l-Histidine-Derived Smart Antifouling Biohybrid with Multistimuli Responsivity
Biomacromolecules ( IF 5.5 ) Pub Date : 2021-08-04 , DOI: 10.1021/acs.biomac.1c00748 Sk Arif Mohammad 1 , Subrata Dolui 1 , Devendra Kumar 1 , Shivshankar R Mane 2 , Sanjib Banerjee 1
Biomacromolecules ( IF 5.5 ) Pub Date : 2021-08-04 , DOI: 10.1021/acs.biomac.1c00748 Sk Arif Mohammad 1 , Subrata Dolui 1 , Devendra Kumar 1 , Shivshankar R Mane 2 , Sanjib Banerjee 1
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A novel dual pH/thermoresponsive amphiphilic poly(histidine methacrylamide)-block-hydroxyl-terminated polybutadiene-block-poly(histidine methacrylamide) (PHisMAM-b-PB-b-PHisMAM) triblock copolymer biohybrid, composed of hydrophobic PB and ampholytic PHisMAM segments, is developed via direct switching from living anionic polymerization to recyclable nanoparticle catalyst-mediated reversible-deactivation radical polymerization (RDRP). The transformation involved in situ postpolymerization modification of living polybutadiene-based carbanionic species, end-capped with ethylene oxide, into dihydroxyl-terminated polybutadiene and a subsequent reaction with 2-bromo-2-methylpropionyl bromide resulting in a telechelic ATRP macroinitiator (Br–PB–Br). Br–PB–Br was used to mediate RDRP of an l-histidine-derived monomer, HisMAM, yielding a series of PHisMAM-b-PB-b-PHisMAM triblock copolymers. The copolymer’s stimuli response was assessed against pH and temperature changes. The copolymer is capable of switching among its zwitterionic, anionic, and cationic forms and exhibited unique antifouling properties in its zwitterionic form. These novel triblock copolymers are expected to be show promising potential in biomedical applications.
中文翻译：
l-组氨酸衍生的智能防污生物杂化物，具有多刺激响应性
一种新型的双pH值/两亲性热响应聚（甲基丙烯酰胺的组氨酸） -嵌段-羟基-封端的聚丁二烯-嵌段-聚（甲基丙烯酰胺的组氨酸）（PHisMAM- b -PB- b-PHisMAM) 三嵌段共聚物生物杂化物，由疏水性 PB 和两性 PHisMAM 链段组成，是通过从活性阴离子聚合直接转换到可回收纳米颗粒催化剂介导的可逆失活自由基聚合 (RDRP) 来开发的。涉及以环氧乙烷封端的活性聚丁二烯基碳负离子物种的原位后聚合改性转化为二羟基封端的聚丁二烯，随后与 2-溴-2-甲基丙酰溴反应生成遥爪 ATRP 大分子引发剂（Br-PB -Br)。Br-PB-Br 用于介导l-组氨酸衍生单体 HisMAM 的 RDRP，产生一系列 PHisMAM- b -PB- b-PHisMAM 三嵌段共聚物。针对 pH 值和温度变化评估共聚物的刺激响应。该共聚物能够在其两性离子、阴离子和阳离子形式之间切换，并以其两性离子形式表现出独特的防污性能。这些新型三嵌段共聚物有望在生物医学应用中显示出广阔的潜力。
更新日期：2021-09-13
中文翻译：
l-组氨酸衍生的智能防污生物杂化物，具有多刺激响应性
一种新型的双pH值/两亲性热响应聚（甲基丙烯酰胺的组氨酸） -嵌段-羟基-封端的聚丁二烯-嵌段-聚（甲基丙烯酰胺的组氨酸）（PHisMAM- b -PB- b-PHisMAM) 三嵌段共聚物生物杂化物，由疏水性 PB 和两性 PHisMAM 链段组成，是通过从活性阴离子聚合直接转换到可回收纳米颗粒催化剂介导的可逆失活自由基聚合 (RDRP) 来开发的。涉及以环氧乙烷封端的活性聚丁二烯基碳负离子物种的原位后聚合改性转化为二羟基封端的聚丁二烯，随后与 2-溴-2-甲基丙酰溴反应生成遥爪 ATRP 大分子引发剂（Br-PB -Br)。Br-PB-Br 用于介导l-组氨酸衍生单体 HisMAM 的 RDRP，产生一系列 PHisMAM- b -PB- b-PHisMAM 三嵌段共聚物。针对 pH 值和温度变化评估共聚物的刺激响应。该共聚物能够在其两性离子、阴离子和阳离子形式之间切换，并以其两性离子形式表现出独特的防污性能。这些新型三嵌段共聚物有望在生物医学应用中显示出广阔的潜力。
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