Abstract

The ethanolamine-modified polylactide (ETA-PLLA) nanofibrous microsphere was fabricated by emulsification combine with a thermally induced phase separation method. The drug loading density of loxoprofen Sodium was 11.5%, the drug loading density of ibuprofen was 2.25%, which should be attributed to the hydrophilic of ETA-PLLA. The nanofibrous injectable microspheres have a slow release effect with the loxoprofen sodium, it can prolong the time of the action of drugs in the body, reduce the side effects of drugs. It indicated that the microspheres can be used for drug loading, and it is also expected to be used for cell carriers.

中文翻译：

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乙醇胺改性聚丙交酯改性载药纳米纤维微球支架的制备

摘要

采用乳化结合热致相分离法制备乙醇胺改性聚乳酸​​（ETA-PLLA）纳米纤维微球。洛索洛芬钠的载药密度为11.5%，布洛芬的载药密度为2.25%，这应归因于ETA-PLLA的亲水性。纳米纤维注射用微球与洛索洛芬钠具有缓释作用，可延长药物在体内的作用时间，减少药物的副作用。表明微球可用于载药，也有望用于细胞载体。