Fast screening of Depolymerized Lignin Samples Through 2D-Liquid Chromatography Mapping,ChemistryOpen

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Fast screening of Depolymerized Lignin Samples Through 2D-Liquid Chromatography Mapping
ChemistryOpen ( IF 2.5 ) Pub Date : 2021-08-05 , DOI: 10.1002/open.202100088
Tibo De Saegher ₁ , Jeroen Lauwaert ₁ , Joeri Vercammen _{1,

2} , Kevin M Van Geem ₃ , Jeriffa De Clercq ₁ , An Verberckmoes ₁

Affiliation

Lignin valorization and particularly its depolymerization into bio-aromatics, has emerged as an important research topic within green chemistry. However, screening of catalysts and reaction conditions within this field is strongly constrained by the lack of analytical techniques that allow for fast and detailed mapping of the product pools. This analytical gap results from the inherent product pool complexity and the focus of the state-of-the-art on monomers and dimers, overlooking the larger oligomers. In this work, this gap is bridged through the development of a quasi-orthogonal GPC-HPLC-UV/VIS method that is able to separate the bio-aromatics according to molecular weight (hydrodynamic volume) and polarity. The method is evaluated using model compounds and real lignin depolymerization samples. The resulting color plots provide a powerful graphical tool to rapidly assess differences in reaction selectivity towards monomers and dimers as well as to identify differences in the oligomers.

中文翻译：

通过二维液相色谱图谱快速筛选解聚木质素样品

木质素的增值，特别是其解聚成生物芳香烃，已成为绿色化学领域的一个重要研究课题。然而，由于缺乏能够快速、详细地绘制产物池的分析技术，该领域的催化剂和反应条件的筛选受到严重限制。这种分析差距是由于固有的产品池复杂性以及最先进技术对单体和二聚体的关注而忽视了较大的低聚物造成的。在这项工作中，通过开发准正交 GPC-HPLC-UV/VIS 方法弥补了这一差距，该方法能够根据分子量（流体动力学体积）和极性分离生物芳香族化合物。使用模型化合物和真实木质素解聚样品对该方法进行评估。由此产生的颜色图提供了一个强大的图形工具，可以快速评估对单体和二聚体的反应选择性差异，以及识别低聚物中的差异。

更新日期：2021-08-05

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