Using synthetic PEG-NAD(H) cofactor swing arms, we demonstrate the modular assembly of dehydrogenases to produce a series of novel, self-contained synthetic transhydrogenases. We also show that the stabilities and catalytic properties of the resulting transhydrogenases are improved without detriment to the selectivities of the native active sites.

中文翻译：

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NAD(H)-PEG 摆臂提高了具有可预测选择性的模块化组装转氢酶的活性和稳定性

我们使用合成的 PEG-NAD(H) 辅因子摇臂，展示了脱氢酶的模块化组装，以生产一系列新颖的、独立的合成转氢酶。我们还表明，所得转氢酶的稳定性和催化性能得到改善，而不会损害天然活性位点的选择性。