S-Denitrosylase-Like Activity of Cyclic Diselenides Conjugated with Xaa-His Dipeptide: Role of Proline Spacer as a Key Activity Booster,ChemBioChem

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S-Denitrosylase-Like Activity of Cyclic Diselenides Conjugated with Xaa-His Dipeptide: Role of Proline Spacer as a Key Activity Booster
ChemBioChem ( IF 2.6 ) Pub Date : 2021-08-04 , DOI: 10.1002/cbic.202100394
Rumi Mikami ₁ , Shunsuke Tsukagoshi ₁ , Yoshiki Oda ₂ , Kenta Arai ₁

Affiliation

1,2-Diselenan-4-amine conjugated with Pro-His dipeptide, a novel S-denitrosylase mimic, effectively promoted the cysteinyl S-denitrosylation and prevented protein misfolding caused by the S-nitrosylation. Structural analyses of the compound suggested that the diselenol form, which is produced as a key reactive species during the catalytic reaction, is thermodynamically stabilized by forming a γ-turn, dramatically enhancing the catalytic activity.

中文翻译：

与 Xaa-His 二肽缀合的环状二硒化物的 S-脱亚硝基酶样活性：脯氨酸间隔物作为关键活性促进剂的作用

1,2-Diselenan-4-amine与 Pro-His 二肽结合，一种新型的S-脱硝基化酶模拟物，有效促进半胱氨酰S-脱硝基化并防止S-亚硝基化引起的蛋白质错误折叠。该化合物的结构分析表明，在催化反应过程中作为关键活性物质产生的二硒醇形式通过形成 γ-转角而在热力学上稳定，从而显着提高了催化活性。

更新日期：2021-08-04

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