Objective

The aim was to find a sensitive method to highlight the remodeling of the brain’s bioelectric activity in post-stroke repair.

Methods

Fifteen mild upper limb paretic stroke patients and age-matched healthy controls were included. Repeated trials of finger tapping around the 10th and 100th days after stroke onset were recorded with a 128-channel EEG. Power spectra and Inter Trial Coherence (ITC) calculations were synchronized to tappings. ITC was correlated with motor performance.

Results

ITC, in low frequency bands, designates the motor related bioelectric activity in channel space in both healthy subjects and patients. Ten days after stroke onset, delta-theta ITC was severely reduced compared to baseline, while three months later ITC reorganized partially over the ipsilesional central-parietal areas reflecting the improvement of motor networks. Decreased ITC in the central-parietal area remained significant compared to controls. Delta band ITC over the dorsolateral-prefrontal cortex correlates with the performance on Nine Hole Peg Test. At post-recovery, non-paretic hand tappings show significantly decreased delta-theta ITC over the supplementary motor area, which reflects network remodeling.

Conclusions

Inter Trial Coherence is a useful measure of brain reorganization during stroke recovery.

Significance

Delta- theta ITC is a sensitive indicator of impaired motor execution.

中文翻译：

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卒中恢复过程中低频振荡的试验间相干性

客观的

目的是找到一种敏感的方法来突出中风后修复中大脑生物电活动的重塑。

方法

包括 15 名轻度上肢麻痹性中风患者和年龄匹配的健康对照。中风发作后第 10 天和第 100 天左右手指敲击的重复试验用 128 通道 EEG 记录。功率谱和试验间相干性 (ITC) 计算与攻丝同步。ITC 与运动表现相关。

结果

ITC 在低频段中表示健康受试者和患者通道空间中与运动相关的生物电活动。中风发作后 10 天，delta-theta ITC 与基线相比严重降低，而三个月后 ITC 在同侧中央顶叶区域部分重组，反映了运动网络的改善。与对照组相比，中央顶叶区域的 ITC 降低仍然显着。背外侧前额叶皮层上的 Delta 带 ITC 与九孔钉测试的表现相关。在恢复后，非麻痹手敲击显示辅助运动区域的 delta-theta ITC 显着降低，这反映了网络重塑。

结论

试验间一致性是中风恢复期间大脑重组的有用措施。

意义

Delta-theta ITC 是运动执行受损的敏感指标。