Copeptin and insulin-like growth factor-1 predict long-term outcomes after aneurysmal subarachnoid hemorrhage: A large prospective cohort study,Clinical Neurology and Neurosurgery

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Copeptin and insulin-like growth factor-1 predict long-term outcomes after aneurysmal subarachnoid hemorrhage: A large prospective cohort study
Clinical Neurology and Neurosurgery ( IF 1.8 ) Pub Date : 2021-08-05 , DOI: 10.1016/j.clineuro.2021.106863
Liheng Bian ₁ , Jinxi Lin ₁ , Yanfang Liu ₂ , Jingjing Lu ₂ , Xingquan Zhao ₃

Affiliation

Objective

The predictive roles of copeptin and insulin-like growth factor-1 (IGF-1) in aneurysmal subarachnoid hemorrhage (aSAH) remain controversial. We aimed to define the relationship between copeptin and IGF-1 levels and functional outcome as well as quality of life (QoL) after aSAH.

Methods

Patients with aSAH were prospectively enrolled in a tertiary university hospital. Controls were sex- and age-matched healthy subjects. Plasma concentrations of copeptin and IGF-1 were measured on admission. Demographics and clinical, radiological and laboratory characteristics of the patients were collected. Favorable functional outcome was defined as modified Rankins $\leq$ 2, and QoL was evaluated by the 36-Item Short Form Health Survey (SF-36) 1 year after aSAH. Uni- and multivariable analyses were performed.

Results

One hundred eighteen patients were eligible, with 122 healthy controls were included in this study. Plasma copeptin levels were significantly higher and plasma IGF-1 was lower in patients than in controls. Both copeptin (adjusted HR 4.143 [1.120–15.328], p = 0.033) and IGF-1 levels (adjusted HR 0.089 [0.013–0.602], p = 0.013) were positively associated with 1-year mortality, while only single copeptin and IGF-1 concentrations were independent predictors of poor functional outcome and QoL, respectively.

Conclusions

Plasma copeptin and IGF-1 levels are abnormal in patients with acute aSAH, and this may reliably predict long-term mortality, functional outcome and QoL.

中文翻译：

和肽素和胰岛素样生长因子-1 预测动脉瘤性蛛网膜下腔出血后的长期预后：一项大型前瞻性队列研究

客观的

和肽素和胰岛素样生长因子-1 (IGF-1) 在动脉瘤性蛛网膜下腔出血 (aSAH) 中的预测作用仍存在争议。我们旨在确定 aSAH 后和肽素和 IGF-1 水平与功能结果以及生活质量 (QoL) 之间的关系。

方法

aSAH 患者被前瞻性纳入三级大学医院。对照组是性别和年龄匹配的健康受试者。入院时测量和肽素和 IGF-1 的血浆浓度。收集了患者的人口统计学和临床、放射学和实验室特征。良好的功能结果被定义为改良的 Rankins $\leq$ 2，QoL 在 aSAH 后 1 年通过 36 项简短健康调查 (SF-36) 进行评估。进行了单变量和多变量分析。

结果

118 名患者符合条件，其中 122 名健康对照被纳入本研究。患者的血浆和肽素水平显着高于对照组，血浆 IGF-1 低于对照组。和肽素（调整后的 HR 4.143 [1.120-15.328]，p = 0.033）和 IGF-1 水平（调整后的 HR 0.089 [0.013-0.602]，p = 0.013）与 1 年死亡率呈正相关，而只有单一的和肽素和 IGF -1 浓度分别是不良功能结果和 QoL 的独立预测因子。