Amphiphilic polymeric nanocarriers have attained immense attention for transporting drugs and other bioactive species to the living systems owing to their high loading capacity and efficient internalization. To avoid the side-effects of undesired interactions within the biological system, the use of biocompatible building blocks is most crucial in preparing polymeric amphiphiles. The excellent biocompatibility and multivalency of both glycerol and triglycerol make them suitable monomers to construct macromolecular skeletons. Besides these, easy availability and remarkable aqueous solubility further enlarge their use in synthetic chemistry and give ample possibilities for creating fascinating entities for practical applications. The conversion of glycerol into azido-glycerol and azido-triglycerol further helped in differential functionalization of their polymers with various hydrophobic and hydrophilic groups in different ratios thereby assisting in tuning the amphiphilicity of resulting functionalized polymers. Herein, we review the enzymatic synthesis of glycerol, azido-glycerol and azido-triglycerol based amphiphilic polymeric architectures as nanocarriers for various bio-active species. Enzymatically synthesized linear copolymers synthesized by selective esterification of primary hydroxyl groups of glycerol and its derivatives with suitable diacids/diesters are explored in this review.

两亲聚合物纳米载体由于其高负载能力和有效的内化，在将药物和其他生物活性物质运输到生命系统方面受到了极大的关注。为了避免生物系统内不希望的相互作用的副作用，使用生物相容性构建块在制备聚合两亲物时最为关键。甘油和三甘油的优异生物相容性和多价性使它们成为构建大分子骨架的合适单体。除此之外，易于获得和显着的水溶性进一步扩大了它们在合成化学中的应用，并为创造用于实际应用的迷人实体提供了充足的可能性。甘油向叠氮甘油和叠氮甘油的转化进一步有助于具有不同比例的各种疏水和亲水基团的聚合物的差异官能化，从而有助于调节所得官能化聚合物的两亲性。在此，我们回顾了基于甘油、叠氮基甘油和叠氮基甘油三酯的两亲聚合物结构作为各种生物活性物质的纳米载体的酶促合成。本综述探讨了通过甘油及其衍生物的伯羟基与合适的二酸/二酯选择性酯化而合成的酶法合成线性共聚物。我们回顾了基于甘油、叠氮基甘油和叠氮基甘油三酯的两亲聚合物结构作为各种生物活性物质的纳米载体的酶促合成。本综述探讨了通过甘油及其衍生物的伯羟基与合适的二酸/二酯选择性酯化而合成的酶法合成线性共聚物。我们回顾了基于甘油、叠氮基甘油和叠氮基甘油三酯的两亲聚合物结构作为各种生物活性物质的纳米载体的酶促合成。本综述探讨了通过甘油及其衍生物的伯羟基与合适的二酸/二酯选择性酯化而合成的酶法合成线性共聚物。