The present study is the synthesis of new heterocyclic moieties like pyrazole, isoxazole and thiazole containing benzimidazole nucleus. The title compounds were synthesized from 4-(1H-benzo[d]imidazol-2-yl) oxazol-2-amine. The newly synthesised compounds were screened for their in vitro anti-inflammatory activity and demonstrated excellent to moderate activity and molecular docking study reports are supporting anti-inflammatory activity showed high inhibition constant and binding energy. The structures of synthesised compounds were characterized by IR, 1HNMR, Mass spectroscopic methods.

中文翻译：

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作为抗炎剂的新型吡唑和异恶唑衍生物的有效合成、体外和计算机评价

目前的研究是合成新的杂环部分，如含有苯并咪唑核的吡唑、异恶唑和噻唑。标题化合物由4-(1H-苯并[d]咪唑-2-基)恶唑-2-胺合成。对新合成的化合物进行了体外抗炎活性筛选，并显示出优异至中等的活性，分子对接研究报告支持抗炎活性，显示出高抑制常数和结合能。合成化合物的结构通过IR、1HNMR、质谱等方法表征。