Altered Structural Brain Networks in Refractory and Nonrefractory Idiopathic Generalized Epilepsy,Brain Connectivity

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Altered Structural Brain Networks in Refractory and Nonrefractory Idiopathic Generalized Epilepsy
Brain Connectivity ( IF 2.4 ) Pub Date : 2022-08-04 , DOI: 10.1089/brain.2021.0035
Andrea McKavanagh _{1,

2} , Barbara A K Kreilkamp _{1,

2,

3} , Yachin Chen _{1,

2} , Christine Denby ₂ , Martyn Bracewell _{2,

4,

5} , Kumar Das ₂ , Christophe De Bezenac _{1,

2} , Anthony G Marson _{1,

2} , Peter N Taylor ₆ , Simon S Keller _{1,

2}

Affiliation

Introduction: Idiopathic generalized epilepsy (IGE) is a collection of generalized nonlesional epileptic network disorders. Around 20–40% of patients with IGE are refractory to antiseizure medication, and mechanisms underlying refractoriness are poorly understood. Here, we characterize structural brain network alterations and determine whether network alterations differ between patients with refractory and nonrefractory IGE.

中文翻译：

难治性和非难治性特发性全身性癫痫的大脑结构网络改变

简介：特发性全身性癫痫（IGE）是全身性非病变性癫痫网络疾病的集合。大约 20-40% 的 IGE 患者对抗癫痫药物耐药，而耐药机制尚不清楚。在这里，我们描述了大脑网络结构改变的特征，并确定难治性和非难治性 IGE 患者之间的网络改变是否不同。

更新日期：2022-08-05

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