The Klotho protein family plays important roles in several metabolic pathways. Soluble Klotho has been recently put forward as an antiaging protein, demonstrating renal and cardiovascular protective traits. Cardiopulmonary bypass (CPB) support during cardiac surgery has been implicated in several adverse outcomes in pediatric and adult patients. Our goal was to assess whether serum Klotho levels can be used to predict outcomes in children undergoing cardiac surgery with CPB due to congenital heart defects (CHDs).

中文翻译：

---

可溶性 Klotho 对接受体外循环支持的心脏手术的儿科患者的保护作用——一项初步研究

Klotho 蛋白家族在多种代谢途径中发挥着重要作用。可溶性 Klotho 最近被提出作为一种抗衰老蛋白，具有肾脏和心血管保护特性。心脏手术期间的体外循环 (CPB) 支持与儿科和成人患者的一些不良后果有关。我们的目标是评估血清 Klotho 水平是否可用于预测因先天性心脏缺陷 (CHD) 接受 CPB 心脏手术的儿童的结局。