Phosphorylcholine (PC) has been used to improve the water solubility and biocompatibility of biomaterials. Here, we show that PC can also work as a ligand for targeting cancer cells based on their increased phospholipid metabolism. PC-installed multiarm poly(ethylene glycol)s and polymeric micelles achieved high and rapid internalization in pancreatic cancer cells. This enhanced cellular uptake was drastically reduced when the cells were incubated with excess free PC or at 4 °C, as well as by inhibiting the phospholipid transfer protein (PLTP) on the surface of cancer cells, indicating an energy dependent active transport mediated by PLTP.

中文翻译：

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磷酸胆碱纳米载体通过磷脂转移蛋白靶向胰腺癌细胞

磷酰胆碱 (PC) 已被用于改善生物材料的水溶性和生物相容性。在这里，我们展示了 PC 还可以作为一种配体，根据增加的磷脂代谢来靶向癌细胞。安装在 PC 上的多臂聚（乙二醇）和聚合物胶束在胰腺癌细胞中实现了高度快速的内化。当细胞与过量的游离 PC 一起孵育或在 4°C 下，以及通过抑制癌细胞表面的磷脂转移蛋白 (PLTP) 时，这种增强的细胞摄取显着减少，表明由 PLTP 介导的能量依赖性主动转运.