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Self-Adaptable Tropos Catalysts
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2021-08-04 , DOI: 10.1021/acs.accounts.1c00326 Montserrat Diéguez 1 , Oscar Pàmies 1 , Christina Moberg 2
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2021-08-04 , DOI: 10.1021/acs.accounts.1c00326 Montserrat Diéguez 1 , Oscar Pàmies 1 , Christina Moberg 2
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Biological systems have often served as inspiration for the design of synthetic catalysts. The lock and key analogy put forward by Emil Fischer in 1894 to explain the high substrate specificity of enzymes has been used as a general guiding principle aimed at enhancing the selectivity of chemical processes by optimizing attractive and repulsive interactions in molecular recognition events. However, although a perfect fit of a substrate to a catalytic site may enhance the selectivity of a specific catalytic reaction, it inevitably leads to a narrow substrate scope, excluding substrates with different sizes and shapes from efficient binding. An ideal catalyst should instead be able to accommodate a wide range of substrates—it has indeed been recognized that enzymes also are often highly promiscuous as a result of their ability to change their conformation and shape in response to a substrate—and preferentially be useful in various types of processes. In biological adaptation, the process by which species become fitted to new environments is crucial for their ability to cope with changing environmental conditions. With this in mind, we have been exploring catalytic systems that can adapt their size and shape to the environment with the goal of developing synthetic catalysts with wide scope.
中文翻译：
自适应 Tropos 催化剂
生物系统经常成为合成催化剂设计的灵感。埃米尔·费舍尔 (Emil Fischer) 于 1894 年提出的锁和钥匙类比，用于解释酶的高底物特异性，已被用作一般指导原则，旨在通过优化分子识别事件中的吸引和排斥相互作用来增强化学过程的选择性。然而，虽然底物与催化位点的完美配合可以提高特定催化反应的选择性，但它不可避免地导致底物范围狭窄，将不同尺寸和形状的底物排除在有效结合之外。相反，理想的催化剂应该能够适应多种底物——人们确实认识到，酶通常也具有高度混杂性，因为它们能够响应底物而改变其构象和形状——并且优先用于各种类型的流程。在生物适应中，物种适应新环境的过程对于它们应对不断变化的环境条件的能力至关重要。考虑到这一点，我们一直在探索能够使其尺寸和形状适应环境的催化系统，目标是开发具有广泛用途的合成催化剂。
更新日期：2021-08-17
中文翻译：
自适应 Tropos 催化剂
生物系统经常成为合成催化剂设计的灵感。埃米尔·费舍尔 (Emil Fischer) 于 1894 年提出的锁和钥匙类比，用于解释酶的高底物特异性，已被用作一般指导原则，旨在通过优化分子识别事件中的吸引和排斥相互作用来增强化学过程的选择性。然而，虽然底物与催化位点的完美配合可以提高特定催化反应的选择性，但它不可避免地导致底物范围狭窄，将不同尺寸和形状的底物排除在有效结合之外。相反，理想的催化剂应该能够适应多种底物——人们确实认识到，酶通常也具有高度混杂性，因为它们能够响应底物而改变其构象和形状——并且优先用于各种类型的流程。在生物适应中，物种适应新环境的过程对于它们应对不断变化的环境条件的能力至关重要。考虑到这一点，我们一直在探索能够使其尺寸和形状适应环境的催化系统，目标是开发具有广泛用途的合成催化剂。
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