Introduction Grip strength has been associated with chronic diseases and mortality. However, current evidence of the association between grip strength and incident type 2 diabetes mellitus (T2DM) is controversial. The aim of this study was to investigate the associations of absolute and relative grip strength with incident T2DM and whether these associations differ by sociodemographic, lifestyle and adiposity-related factors. Research design and methods This was a prospective cohort study of 166 894 participants in the UK Biobank (mean age 56.5 years, 54.4% women). The outcome was T2DM incidence and the exposure was grip strength, expressed in absolute (kg) and relative (kg per kg of body weight) values. The association between grip strength and T2DM incidence was investigated using Cox-proportional regression. Results The median follow-up was 5.3 years (IQR: 4.7–6.1). During this time, 3713 participants developed T2DM. Lower grip strength was associated with a higher risk of T2DM in both sexes. Those in the lowest quintile of absolute grip strength had a 50% higher risk in men (HR: 1.50 (95% CI: 1.30 to 1.73)) and 25% higher risk in women (HR: 1.25 (95% CI: 1.06 to 1.47)) compared with those in the highest quintile. For relative grip strength, risk of diabetes was more than double for men (HR: 2.22 (95% CI: 1.84 to 2.67)) and 96% higher for women (HR: 1.96 (95% CI: 1.52 to 2.53)) in the lowest compared with highest quintiles. Conclusions Grip strength is associated with a higher risk of T2DM incidence in both men and women independent of important confounding factors including age, deprivation, adiposity and lifestyle. However, the associations were stronger when grip strength is expressed relative to body weight, which could reflect the importance of muscle quality. Data are available upon reasonable request. Data can be obtained upon request to UK Biobank.

中文翻译：

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握力与 2 型糖尿病事件之间的关联：来自英国生物银行前瞻性队列研究的结果

简介 握力与慢性疾病和死亡率有关。然而，目前关于握力与发生 2 型糖尿病 (T2DM) 之间关联的证据存在争议。本研究的目的是调查绝对和相对握力与 T2DM 事件的关联，以及这些关联是否因社会人口、生活方式和肥胖相关因素而异。研究设计和方法 这是一项前瞻性队列研究，涉及英国生物银行的 166 894 名参与者（平均年龄 56.5 岁，54.4% 为女性）。结果是 T2DM 发病率，暴露是握力，以绝对 (kg) 和相对 (kg/kg 体重) 值表示。使用 Cox 比例回归研究了握力与 T2DM 发病率之间的关联。结果中位随访时间为 5 次。3 年（IQR：4.7–6.1）。在此期间，3713 名参与者患上了 T2DM。较低的握力与较高的两性 T2DM 风险相关。绝对握力最低五分之一的男性风险高出 50%（HR：1.50（95% CI：1.30 至 1.73）），女性风险高 25%（HR：1.25（95% CI：1.06 至 1.47） )) 与最高五分之一的人相比。在相对握力方面，男性患糖尿病的风险是男性的两倍多（HR：2.22（95% CI：1.84 至 2.67）），女性则高出 96%（HR：1.96（95% CI：1.52 至 2.53））。与最高五分位数相比，最低。结论 握力与男性和女性的 T2DM 发病率较高相关，与年龄、剥夺、肥胖和生活方式等重要混杂因素无关。然而，当握力相对于体重表示时，这种关联更强，这可以反映肌肉质量的重要性。可根据合理要求提供数据。数据可向英国生物银行索取。