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Paper-based microfluidic devices: On-site tools for crime scene investigation
Trends in Analytical Chemistry ( IF 11.8 ) Pub Date : 2021-08-05 , DOI: 10.1016/j.trac.2021.116406
Giacomo Musile , Yvane Agard , Ling Wang , Elio Franco De Palo , Bruce McCord , Franco Tagliaro

The use of paper-based microfluidics devices (μPADs) for designing rapid, easy, and on-site devices has undergone a dramatic increase in the last few years and the development of applications in the field of forensic science has had concomitant advances. The use of μPADs at the crime scene is finalized not only to obtain a rapid response but also to have crucial information on evidence collection.

Several authors have proposed μPADs as alternative approaches to existing tests. These devices are designed to be used on-site without, or minimal, power sources. Furthermore, the technology provides prompt-readouts using a small sample volume, preserving important evidence for instrumental analysis.

This review aims to provide a critical evaluation of developed μPADs. The document includes a brief overview on fabrication methods and on detection strategies, and it assesses advantages and limitations of applications related to forensic matters. A final section is devoted to future developments.



中文翻译:

纸基微流体设备:犯罪现场调查的现场工具

在过去几年中,使用纸基微流体设备 (μPAD) 来设计快速、简单和现场设备的情况急剧增加,法医科学领域的应用开发也随之取得了进展。最终确定在犯罪现场使用 μPAD 不仅是为了获得快速反应,而且是为了获得有关证据收集的关键信息。

几位作者提出了 μPAD 作为现有测试的替代方法。这些设备设计用于在没有或极少电源的情况下在现场使用。此外,该技术使用小样本量提供即时读数,为仪器分析保留重要证据。

本综述旨在对开发的 μPAD 进行批判性评估。该文件包括对制造方法和检测策略的简要概述,并评估了与法医事项相关的应用的优势和局限性。最后一部分专门讨论未来的发展。

更新日期:2021-08-11
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