The sequence, length and substitution of a polysaccharide influence its physical and biological properties. Thus, sequence controlled polysaccharides are important targets to establish structure–properties correlations. Polymerization techniques and enzymatic methods have been optimized to obtain samples with well-defined substitution patterns and narrow molecular weight distribution. Chemical synthesis has granted access to polysaccharides with full control over the length. Here, we review the progress towards the synthesis of well-defined polysaccharides. For each class of polysaccharides, we discuss the available synthetic approaches and their current limitations.

中文翻译：

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序列控制多糖合成的进展与挑战


多糖的序列、长度和取代会影响其物理和生物特性。因此，序列控制的多糖是建立结构-性质相关性的重要目标。聚合技术和酶法已经过优化，以获得具有明确取代模式和窄分子量分布的样品。化学合成已经允许获得多糖并完全控制长度。在这里，我们回顾了明确多糖合成的进展。对于每一类多糖，我们讨论了可用的合成方法及其当前的局限性。