Abnormal changes in hippocampal function and neuroplasticity are involved in neuropathic pain, which induces hyperalgesia and learning and memory deficits. Previous studies from our group have shown that electroacupuncture at Huantiao (GB30) and Yanglingquan (GB34) has an obvious analgesic effect on neuropathic pain. However, the central regulatory mechanism occurring in the hippocampus remains to be investigated. In this study, behavioral and proteomic analyses were performed to identify differentially expressed hippocampal proteins involved in electroacupuncture-induced analgesia. Our results showed both upregulated (TMEM126A, RDH13, and Luc7L) and downregulated proteins (Mettl7A, GGA1 RTKN, RSBN1, and CDKN1B). Further protein verification revealed for the first time that hippocampal TMEM126A plays an important anti-inflammatory role in the treatment of neuralgia by electroacupuncture.

中文翻译：

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神经性疼痛大鼠海马的差异蛋白质组学分析以研究电针在缓解机械性异常性疼痛和认知衰退中的应用

海马功能和神经可塑性的异常变化与神经性疼痛有关，会引起痛觉过敏和学习记忆障碍。本组前期研究表明，电针环跳（GB30）和阳陵泉（GB34）对神经性疼痛有明显的镇痛作用。然而，海马中发生的中枢调节机制仍有待研究。在这项研究中，进行了行为和蛋白质组学分析，以确定与电针诱导的镇痛有关的差异表达的海马蛋白。我们的结果显示上调（TMEM126A、RDH13 和 Luc7L）和下调蛋白质（Mettl7A、GGA1 RTKN、RSBN1 和 CDKN1B）。