Inflammatory bowel disease (IBD) is a group of immune-mediated conditions. Immune activity is varied by age and gender. The present study is aimed at investigating the effect of age and gender on the positive rates of anti-Saccharomyces cerevisiae antibodies (ASCA), anti-neutrophil cytoplasmic antibodies (ANCA), anti-intestinal goblet cell antibodies (GAB), and antibodies to exocrine pancreas (PAB) in IBD patients. A total of 1871 hospitalized patients with confirmed IBD were included in this study. Sera were obtained from each subject for antibody measurement by indirect immunofluorescence assay. The positive rates of ANCA IgG and IgA were higher in female patients than those in male patients () while the positive rate of PAB IgG was just reversed (). Moreover, the median ages of patients with positive ANCA IgG and IgA were higher than patients with negative antibodies ( and , respectively), while the median ages of patients with positive PAB IgG and IgA were significantly lower than patients with negative PAB (). The serum levels of ANCA IgG and IgA were potentiated in old female patients, while serum PAB IgG was easy to be detected in the young male patients with IBD.

中文翻译：

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年龄和性别：影响炎症性肠病患者血清 PAB 和 ANCA 的阳性率

炎症性肠病 (IBD) 是一组免疫介导的疾病。免疫活动因年龄和性别而异。本研究旨在探讨年龄和性别对抗酿酒酵母抗体 (ASCA)、抗中性粒细胞胞浆抗体 (ANCA)、抗肠杯状细胞抗体 (GAB) 和外分泌抗体阳性率的影响。 IBD 患者的胰腺 (PAB)。本研究共纳入 1871 名确诊 IBD 住院患者。通过间接免疫荧光测定从每个受试者获得血清用于抗体测量。女性患者 ANCA IgG 和 IgA 阳性率高于男性患者（)而 PAB IgG 的阳性率正好相反 (）。此外，ANCA IgG和IgA阳性患者的中位年龄高于抗体阴性患者。 和 ，分别地），而阳性患者PAB IgG和IgA的年龄中位数比阴性患者PAB均显著降低（）。老年女性患者血清 ANCA IgG 和 IgA 水平升高，而年轻男性 IBD 患者血清 PAB IgG 易于检测。