Objective. To reveal the relationship between interferon-gamma release assay (IGRA) test (Standard ETB-Feron ELISA (TBF)) results performed within 12 months before the COVID-19 pandemic and the frequency of COVID-19 infections and the severity of COVID-19. Methods. The retrospective TBF test results and contact information of 684 patients aged over 18 years who underwent TBF testing between March 11th, 2019, and March 10th, 2020, were obtained. Of the 684 patients contacted by phone, 365 agreed to participate in the study and were enrolled. The patients were divided into three groups (TBF test positive, negative, and indeterminate). The data obtained from the questionnaire were compared statistically. Results. According to the TBF test results, positive (n = 51, 14%), negative (n = 286, 78.3%), and indeterminate (n = 28, 7.7%) groups were compared. The frequency of COVID-19 infections in the indeterminate group was found significantly higher than that in the positive and negative groups (). When the group with COVID-19 (n = 46, 12.6%) was compared with the group without (n = 319, 87.4%), no difference was found in terms of age, sex, body mass index, smoking history and number of cigarettes smoked, TB history, diabetes mellitus, hypertension, coronary artery disease, and biologic and corticosteroid therapy use. Only the frequency of obstructive pulmonary disease was significantly higher in the group without COVID-19 (). Conclusion. The frequency of COVID-19 infection was increased in patients with indeterminate TBF test results. Indeterminate TBF test results may be a guide in terms of risk stratification in groups at risk for COVID-19.

中文翻译：

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大流行前干扰素 γ 释放试验结果与 COVID-19 感染之间的关系：不确定 IFN-γ 释放试验结果的潜在预后价值

客观。揭示 COVID-19 大流行前 12 个月内进行的干扰素-γ 释放测定 (IGRA) 测试（标准 ETB-Feron ELISA (TBF)）结果与 COVID-19 感染频率和 COVID-19 严重程度之间的关系. 方法。获得了 2019 年 3 月 11 日至 2020 年 3 月 10 日期间接受 TBF 检测的 684 名 18 岁以上患者的回顾性 TBF 检测结果和联系方式。在通过电话联系的 684 名患者中，有 365 名同意参加研究并入组。将患者分为三组（TBF测试阳性、阴性和不确定）。从问卷中获得的数据进行了统计比较。结果。根据 TBF 检测结果，阳性（n = 51, 14%)、阴性 ( n  = 286, 78.3%) 和不确定 ( n  = 28, 7.7%) 组进行了比较。发现不确定组的 COVID-19 感染频率显着高于阳性组和阴性组（）。将 COVID-19 感染组 ( n  = 46, 12.6%) 与未感染组 ( n  = 319, 87.4%) 进行比较时，在年龄、性别、体重指数、吸烟史和吸烟人数方面没有发现差异吸烟、结核病史、糖尿病、高血压、冠状动脉疾病以及生物和皮质类固醇治疗的使用。在没有 COVID-19 的组中，只有阻塞性肺疾病的发生率显着更高（）。 结论。TBF 检测结果不确定的患者感染 COVID-19 的频率增加。不确定的 TBF 测试结果可能是 COVID-19 高危人群风险分层的指南。