COPII vesicle biogenesis at the endoplasmic reticulum requires activation of the Sar1 GTPase, which recruits the COP II coat protein complex to drive membrane budding. In this issue of Structure, Joiner and Fromme (2021) investigate the enigmatic structural basis for Sar1 activation by the Sec12 guanine nucleotide exchange factor.

中文翻译：

---

在内质网推动COPII囊泡生物发生

内质网的 COPII 囊泡生物发生需要激活 Sar1 GTPase，Sar1 GTPase 招募 COP II 外壳蛋白复合物以驱动膜出芽。在本期Structure 中，Joiner 和 Fromme (2021) 研究了 Sec12 鸟嘌呤核苷酸交换因子激活 Sar1 的神秘结构基础。