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A tail goes viral by forming an anchor and a tether
Structure ( IF 5.7 ) Pub Date : 2021-08-05 , DOI: 10.1016/j.str.2021.07.004
Elisar Barbar 1 , Aidan Estelle 1
Affiliation  

In this issue of Structure, Aiyer et al. (2021) report NMR structures of BET:MLV IN complexes, highlighting a role for the disordered tail domain of MLV IN in viral integration. These studies expand the understanding of molecular recognition polymorphism in BET complexes and offer insight into cancer and antiviral therapeutics.



中文翻译:

尾巴通过形成锚和系绳而病毒式传播

在本期Structure 中,Aiyer 等人。(2021) 报告了 BET:MLV IN 复合物的 NMR 结构,强调了 MLV IN 无序尾部结构域在病毒整合中的作用。这些研究扩展了对 BET 复合物中分子识别多态性的理解,并提供了对癌症和抗病毒疗法的深入了解。

更新日期:2021-08-05
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