Lineage-specific gene expression programs in multicellular organisms are controlled by balanced ON and OFF signals, amongst which heterochromatin regulates expression by restricting activation cues. A study now provides insights into mammalian heterochromatin organisation, function and interplay with lineage-specific transcription factors.

中文翻译：

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为表达定义异染色质

多细胞生物中的谱系特异性基因表达程序受平衡的 ON 和 OFF 信号控制，其中异染色质通过限制激活线索来调节表达。一项研究现在提供了对哺乳动物异染色质组织、功能和与谱系特异性转录因子相互作用的见解。