Mepolizumab for Eosinophilic Granulomatosis With Polyangiitis: A European Multicenter Observational Study,Arthritis & Rheumatology

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Mepolizumab for Eosinophilic Granulomatosis With Polyangiitis: A European Multicenter Observational Study
Arthritis & Rheumatology ( IF 13.3 ) Pub Date : 2021-08-04 , DOI: 10.1002/art.41943
Alessandra Bettiol ₁ , Maria Letizia Urban ₁ , Lorenzo Dagna ₂ , Vincent Cottin ₃ , Franco Franceschini ₄ , Stefano Del Giacco ₅ , Franco Schiavon ₆ , Thomas Neumann ₇ , Giuseppe Lopalco ₈ , Pavel Novikov ₉ , Chiara Baldini ₁₀ , Carlo Lombardi ₁₁ , Alvise Berti ₁₂ , Federico Alberici ₁₃ , Marco Folci ₁₄ , Simone Negrini ₁₅ , Renato Alberto Sinico ₁₆ , Luca Quartuccio ₁₇ , Claudio Lunardi ₁₈ , Paola Parronchi ₁ , Frank Moosig ₁₉ , Georgina Espígol-Frigolé ₂₀ , Jan Schroeder ₂₁ , Anna Luise Kernder ₂₂ , Sara Monti ₂₃ , Ettore Silvagni ₂₄ , Claudia Crimi ₂₅ , Francesco Cinetto ₂₆ , Paolo Fraticelli ₂₇ , Dario Roccatello ₂₈ , Angelo Vacca ₂₉ , Aladdin J Mohammad ₃₀ , Bernhard Hellmich ₃₁ , Maxime Samson ₃₂ , Elena Bargagli ₃₃ , Jan Willem Cohen Tervaert ₃₄ , Camillo Ribi ₃₅ , Davide Fiori ₁ , Federica Bello ₁ , Filippo Fagni ₁ , Luca Moroni ₂ , Giuseppe Alvise Ramirez ₂ , Mouhamad Nasser ₃ , Chiara Marvisi ₃₆ , Paola Toniati ₃₇ , Davide Firinu ₅ , Roberto Padoan ₆ , Allyson Egan ₃₈ , Benjamin Seeliger ₃₉ , Florenzo Iannone ₈ , Carlo Salvarani ₃₆ , David Jayne ₃₈ , Domenico Prisco ₁ , Augusto Vaglio ₄₀ , Giacomo Emmi ₁ ,

Affiliation

University of Florence, Florence, Italy.
San Raffaele Hospital, IRCCS, Vita-Salute San Raffaele University, Milan, Italy.
Hospices Civils de Lyon and University of Lyon, Lyon, France.
ASST Spedali Civili of Brescia and University of Brescia, Brescia, Italy.
University of Cagliari, Cagliari, Italy.
Azienda Ospedaliera-Universitaria di Padova, Padova, Italy.
Cantonal Hospital St. Gallen, St. Gallen, Switzerland, and Jena University Hospital, Jena, Germany.
Polyclinic Hospital, University of Bari, Bari, Italy.
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Moscow, Russia.
University of Pisa, Pisa, Italy.
Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy.
Santa Chiara Hospital and University of Trento, Trento, Italy.
University of Brescia and Spedali Civili Hospital, ASST Spedali Civili di Brescia, Brescia, Italy.
Humanitas Clinical and Research Center, IRCCS and Humanitas University, IRCCS, Milan, Italy.
IRCCS Ospedale Policlinico San Martino and University of Genoa, Genoa, Italy.
University of Milano Bicocca, Monza, Italy.
University of Udine, Azienda sanitaria universitaria Friuli Centrale Udine, Udine, Italy.
University of Verona, Italy.
Rheumazentrum Schleswig-Holstein Mitte, Neumünster, Germany.
Hospital Clínic, University of Barcelona and Institut d'investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.
ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Policlinico S. Matteo Fondazione, IRCCS, University of Pavia, Pavia, Italy.
University of Ferrara, Ferrara, Italy.
Policlinico-Vittorio Emanuele San Marco University Hospital, Catania, Italy.
University of Padova, Padova, Italy.
University Hospital Ospedali Riuniti, Ancona, Italy.
San Giovanni Bosco Hospital and University of Turin, Turin, Italy.
Aldo Moro University of Bari, Bari, Italy.
Lund University, Skåne University Hospital, Lund, Sweden, and University of Cambridge, Cambridge, UK.
Medius Kliniken, University of Tübingen, Kirchheim unter Teck, Germany.
Dijon University Hospital, Dijon, France.
University of Siena, Siena, Italy.
University of Alberta, Edmonton, Alberta, Canada, and Maastricht University, Maastricht, The Netherlands.
University Hospital Center of Lausanne, Lausanne, Switzerland.
Azienda USL-IRCCS di Reggio Emilia, IRCCS, and Università di Modena e Reggio Emilia, Reggio Emilia, Italy.
ASST Spedali Civili of Brescia, Brescia, Italy.
University of Cambridge, Cambridge, UK.
Hannover Medical School, Hannover, Germany.
University of Florence and Meyer Children's Hospital, Florence, Italy.

Mepolizumab proved to be an efficacious treatment for eosinophilic granulomatosis with polyangiitis (EGPA) at a dose of 300 mg every 4 weeks in the randomized, controlled MIRRA trial. In a few recently reported studies, successful real-life experiences with the approved dose for treating severe eosinophilic asthma (100 mg every 4 weeks) were observed. We undertook this study to assess the effectiveness and safety of mepolizumab 100 mg every 4 weeks and 300 mg every 4 weeks in a large European EGPA cohort.

中文翻译：

美泊利单抗治疗嗜酸性肉芽肿伴多血管炎：一项欧洲多中心观察性研究

在随机对照 MIRRA 试验中，每 4 周 300 毫克的美泊利单抗被证明是治疗嗜酸性肉芽肿伴多血管炎 (EGPA) 的有效方法。在最近报道的一些研究中，观察到使用批准的剂量（每 4 周 100 毫克）治疗严重嗜酸性粒细胞性哮喘的成功现实生活经验。我们进行了这项研究，以在欧洲大型 EGPA 队列中评估每 4 周 100 mg 和每 4 周 300 mg 的美泊利单抗的有效性和安全性。

更新日期：2021-08-04

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