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Activated Peripheral Blood B Cells in Rheumatoid Arthritis and Their Relationship to Anti–Tumor Necrosis Factor Treatment and Response: A Randomized Clinical Trial of the Effects of Anti–Tumor Necrosis Factor on B Cells
Arthritis & Rheumatology ( IF 11.4 ) Pub Date : 2021-08-04 , DOI: 10.1002/art.41941
Nida Meednu 1 , Jennifer Barnard 1 , Kelly Callahan 1 , Andreea Coca 1 , Bethany Marston 1 , Ralf Thiele 1 , Darren Tabechian 1 , Marcy Bolster 2 , Jeffrey Curtis 3 , Meggan Mackay 4 , Jonathan Graf 5 , Richard Keating 6 , Edwin Smith 2 , Karen Boyle 7 , Lynette Keyes-Elstein 7 , Beverly Welch 8 , Ellen Goldmuntz 8 , Jennifer H Anolik 1
Affiliation  

B cells can become activated in germinal center (GC) reactions in secondary lymphoid tissue and in ectopic GCs in rheumatoid arthritis (RA) synovium that may be tumor necrosis factor (TNF) and lymphotoxin (LT) dependent. This study was undertaken to characterize the peripheral B cell compartment longitudinally during anti-TNF therapy in RA.

中文翻译:

类风湿性关节炎中活化的外周血 B 细胞及其与抗肿瘤坏死因子治疗和反应的关系:抗肿瘤坏死因子对 B 细胞影响的随机临床试验

B 细胞可以在次级淋巴组织的生发中心 (GC) 反应和类风湿性关节炎 (RA) 滑膜中的异位 GC 中被激活,这可能是肿瘤坏死因子 (TNF) 和淋巴毒素 (LT) 依赖性的。本研究旨在纵向描述 RA 抗 TNF 治疗期间外周 B 细胞区室的特征。
更新日期:2021-08-04
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