Background: Changes in cell metabolism are a well-known feature of some cancers, and this may be involved in the etiology of tumor formation and progression, as well as tumor heterogeneity. These changes may affect fatty acid metabolism and glycolysis and are required to provide the increase in energy necessary for the high rate of proliferation of cancer cells. Gastrointestinal cancers remain a difficult-to-treat cancer, particularly as they are usually diagnosed at a late stage of disease and are associated with poor outcomes. Summary: Recently, the changes in the metabolic pathways, including the expression of the rate-limiting enzymes involved, have been considered to be a potential target for therapy for gastrointestinal tumors. Key Message: A combination of routine chemotherapy drugs with metabolic inhibitors may improve the effectiveness of treatment.
Gastrointest Tumors

中文翻译：

---

葡萄糖和脂质代谢途径变化在胃肠道癌症进展中的潜在作用：癌症治疗策略

背景：细胞代谢的变化是一些癌症的一个众所周知的特征，这可能与肿瘤形成和进展的病因学以及肿瘤异质性有关。这些变化可能会影响脂肪酸代谢和糖酵解，并且需要提供癌细胞高速增殖所需的能量增加。胃肠道癌仍然是一种难以治疗的癌症，特别是因为它们通常在疾病晚期被诊断出来并且与不良结果相关。摘要：最近，代谢途径的变化，包括所涉及的限速酶的表达，被认为是治疗胃肠道肿瘤的潜在靶点。关键信息：常规化疗药物与代谢抑制剂的组合可能会提高治疗效果。
胃肠肿瘤