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A very simple model to account for the rapid rise of the alpha variant of SARS-CoV-2 in several countries and the world
Virus Research ( IF 5 ) Pub Date : 2021-08-05 , DOI: 10.1016/j.virusres.2021.198531
Hugo Fort 1
Affiliation  

Since its first detection in the UK in September 2020, a highly contagious version of the coronavirus, the alpha or British variant a.k.a. B.1.1.7 SARS-CoV-2 virus lineage, rapidly spread across several countries and became the dominant strain in the outbreak.

Here it is shown that a very simple evolutionary model can fit the observed change in frequency of B.1.1.7 for several countries, regions of countries and the whole world with a single parameter, its relative fitness f, which is almost universal f ≈ 1.5. This is consistent with a 50% higher transmissibility than the local wild type and with the fact that the period in which this variant takes over has been in all the studied cases around 22 weeks.



中文翻译:

一个非常简单的模型来解释 SARS-CoV-2 的 alpha 变体在几个国家和世界上的快速增长

自 2020 年 9 月在英国首次发现以来,一种高度传染性的冠状病毒版本,即 alpha 或英国变种,又名 B.1.1.7 SARS-CoV-2 病毒谱系,迅速传播到多个国家,并成为该病毒的主要毒株暴发。

这里表明,一个非常简单的进化模型可以用一个参数拟合观察到的几个国家、国家地区和整个世界的 B.1.1.7 频率变化,它的相对适应度f,几乎是普遍的f ≈ 1.5. 这与比本地野生型高 50% 的传播率以及在所有研究案例中该变体接管的时间约为 22 周这一事实是一致的。

更新日期:2021-08-10
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