Stem Cell Reviews and Reports ( IF 4.5 ) Pub Date : 2021-08-04 , DOI: 10.1007/s12015-021-10224-9 Nopmanee Taechangam 1 , Amir Kol 1 , Boaz Arzi 2 , Dori L Borjesson 1
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Multipotent stromal cells (MSCs) are widely utilized in therapy for their immunomodulatory properties, but their usage in infectious viral diseases is less explored. This review aimed to collate the current novel use of MSCs in virus-associated conditions, including MSC’s susceptibility to virus infection, antiviral properties of MSCs and their effects on cell-based immune response and implementation of MSC therapy in animal models and human clinical trials of viral diseases. Recent discoveries shed lights on MSC’s capability in suppressing viral replication and augmenting clearance through enhancement of antiviral immunity. MSC therapy may maintain a crucial balance between aiding pathogen clearance and suppressing hyperactive immune response.
Graphical Abstract
中文翻译：
多能基质细胞和病毒相互作用：当前治疗的意义
多能基质细胞（MSC）因其免疫调节特性而被广泛用于治疗，但其在传染性病毒性疾病中的应用却鲜为人知。本综述旨在整理目前 MSC 在病毒相关疾病中的新用途，包括 MSC 对病毒感染的易感性、MSC 的抗病毒特性及其对细胞免疫反应的影响以及 MSC 治疗在动物模型和人体临床试验中的实施。病毒性疾病。最近的发现揭示了间充质干细胞通过增强抗病毒免疫力抑制病毒复制和增强清除的能力。间充质干细胞疗法可以在帮助病原体清除和抑制过度活跃的免疫反应之间保持至关重要的平衡。
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