Objectives The purpose of the study was to determine the clinical features of NLE and to compare the neonatal outcomes between newborns born to pregnant women with SLE and healthy pregnant women. Methods We conducted a retrospective cohort analysis between 2007 and 2019 in a tertiary referral hospital in Thailand. A total of 118 pregnant women with SLE with 132 neonates compared with 264 randomly selected healthy pregnant women. Results The median (interquartile range) gestational age and birth weight of 132 neonates born to women with SLE were 37 (35–38) weeks and 2687 g (2045–3160 g), respectively. The clinical features of NLE infants were hemolytic anemia (8%), thrombocytopenia (2.7%) and hyperbilirubinemia (5.3%). There was no neonate with a congenital complete heart block or skin lesion. Moreover, logistic regression analysis found that neonates born to women with SLE increased the risk of preterm birth [odd ratio (OR) 8.87, 95% confidence interval (95% CI) 4.32–18.21, p < 0.001], low birth weight (OR 10.35, 95% CI 5.08–21.08, p < 0.001), birth asphyxia (OR 2.91, 95% CI 1.26–6.73, p = 0.011) and NICU admission (OR 4.26, 95% CI 2.44–7.42, p < 0.001). SLE disease activity and corticosteroid and azathioprine usage were associated with preterm delivery in pregnant women with SLE. Conclusion The major clinical features of NLE patients were hematologic and hepatobiliary abnormalities in our study. Pregnancies with SLE dramatically increased the risk of preterm delivery and neonatal complications. Lay summary Neonatal lupus erythematosus (NLE) is the consequence of the transplacental passage of autoantibodies to newborns during pregnancy. The clinical features of NLE infants in our study were hemolytic anemia (8%), thrombocytopenia (2.7%) and hyperbilirubinemia (5.3%). There was no neonate with a congenital complete heart block or skin lesion. We also compared the neonatal outcomes between 118 pregnant women with SLE and 264 randomly selected healthy pregnant women. Our study found that the neonates born to women with SLE increased the risk of preterm birth, low birth weight, birth asphyxia and NICU admission. Moreover, SLE disease activity and corticosteroid and azathioprine usage were associated with preterm delivery in pregnant women with SLE.

中文翻译：

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系统性红斑狼疮孕妇的新生儿结局：泰国南部 13 年经验

目的 本研究的目的是确定 NLE 的临床特征，并比较 SLE 孕妇和健康孕妇所生新生儿的新生儿结局。方法 我们在 2007 年至 2019 年期间在泰国一家三级转诊医院进行了回顾性队列分析。共有 118 名 SLE 孕妇和 132 名新生儿与 264 名随机选择的健康孕妇相比。结果 132 名 SLE 女性所生新生儿的中位（四分位距）胎龄和出生体重分别为 37（35-38）周和 2687 g（2045-3160 g）。NLE婴儿的临床特征为溶血性贫血（8%）、血小板减少（2.7%）和高胆红素血症（5.3%）。没有新生儿先天性完全性心脏传导阻滞或皮肤损伤。而且，逻辑回归分析发现，SLE 女性所生的新生儿增加了早产的风险 [比值比 (OR) 8.87, 95% 置信区间 (95% CI) 4.32–18.21, p <; 0.001]、低出生体重 (OR 10.35, 95% CI 5.08–21.08, p < 0.001)、出生窒息 (OR 2.91, 95% CI 1.26–6.73, p = 0.011) 和 NICU 入院 (OR 4.26, 95% CI 2.44–7.42，p < 0.001)。SLE 疾病活动以及皮质类固醇和硫唑嘌呤的使用与 SLE 孕妇的早产有关。结论 在我们的研究中，NLE 患者的主要临床特征是血液学和肝胆异常。患有 SLE 的妊娠显着增加了早产和新生儿并发症的风险。总结 新生儿红斑狼疮 (NLE) 是妊娠期间自身抗体经胎盘传递给新生儿的结果。我们研究中 NLE 婴儿的临床特征是溶血性贫血 (8%)、血小板减少 (2.7%) 和高胆红素血症 (5.3%)。没有新生儿先天性完全性心脏传导阻滞或皮肤损伤。我们还比较了 118 名 SLE 孕妇和 264 名随机选择的健康孕妇的新生儿结局。我们的研究发现，SLE 女性所生的新生儿增加了早产、低出生体重、出生窒息和 NICU 入院的风险。此外，SLE 疾病活动以及皮质类固醇和硫唑嘌呤的使用与 SLE 孕妇的早产有关。血小板减少症（2.7%）和高胆红素血症（5.3%）。没有新生儿先天性完全性心脏传导阻滞或皮肤损伤。我们还比较了 118 名 SLE 孕妇和 264 名随机选择的健康孕妇的新生儿结局。我们的研究发现，SLE 女性所生的新生儿增加了早产、低出生体重、出生窒息和 NICU 入院的风险。此外，SLE 疾病活动以及皮质类固醇和硫唑嘌呤的使用与 SLE 孕妇的早产有关。血小板减少症（2.7%）和高胆红素血症（5.3%）。没有新生儿先天性完全性心脏传导阻滞或皮肤损伤。我们还比较了 118 名 SLE 孕妇和 264 名随机选择的健康孕妇的新生儿结局。我们的研究发现，SLE 女性所生的新生儿增加了早产、低出生体重、出生窒息和 NICU 入院的风险。此外，SLE 疾病活动以及皮质类固醇和硫唑嘌呤的使用与 SLE 孕妇的早产有关。我们的研究发现，SLE 女性所生的新生儿增加了早产、低出生体重、出生窒息和 NICU 入院的风险。此外，SLE 疾病活动以及皮质类固醇和硫唑嘌呤的使用与 SLE 孕妇的早产有关。我们的研究发现，SLE 女性所生的新生儿增加了早产、低出生体重、出生窒息和 NICU 入院的风险。此外，SLE 疾病活动以及皮质类固醇和硫唑嘌呤的使用与 SLE 孕妇的早产有关。