Almost two decades have passed since the last methamphetamine (METH) abuse epidemic. In recent years, METH abuse in the United States has been rapidly increasing and is currently one of the leading causes of death in our country. Available statistical data indicates reemergence of METH popularity and suggest an impending third epidemic of METH abuse. Alarmingly, there is no FDA-approved medication for METH use disorder (MUD). This disorder is currently treated with behavioral therapies; however, these therapies have limitations and would benefit from the addition of a MUD pharmacotherapy. Unfortunately, clinical trials have not yet found consistently effective pharmacotherapy for MUD. This review outlines the history of METH use, provides information on current prevalence of METH abuse and MUD, describes medications that have been in clinical trials for MUD, and addresses current as well as potential new treatments for MUD.

自上次甲基苯丙胺 (METH) 滥用流行以来，已经过去了将近 20 年。近年来，美国甲基苯丙胺滥用迅速增加，目前已成为我国主要死因之一。可用的统计数据表明 METH 再次流行，并暗示第三次 METH 滥用流行即将到来。令人担忧的是，没有 FDA 批准的用于 METH 使用障碍 (MUD) 的药物。这种疾病目前用行为疗法治疗；然而，这些疗法有局限性，并且将受益于添加 MUD 药物疗法。不幸的是，临床试验尚未发现对 MUD 持续有效的药物治疗。这篇综述概述了 METH 使用的历史，提供了有关当前 METH 滥用和 MUD 流行率的信息，