Methamphetamine (Meth) abuse presents a global problem and commonly occurs with stress and/or alcohol use disorders. Regardless, the biological causes and consequences of these comorbidities are unclear. Whereas the mechanisms of Meth, stress, and alcohol abuse have been examined individually and well-characterized, these processes overlap significantly and can impact the neural and peripheral consequences of Meth. This review focuses on the deleterious cardio- and cerebrovascular effects of Meth, stress, alcohol abuse, and their comorbid effects on the brain and periphery. Points of emphasis are on the composition of the blood-brain barrier and their effects on the heart and vasculature. The autonomic nervous system, inflammation, and oxidative stress are specifically highlighted as common mediators of the toxic consequences to vascular and perivascular health. A significant portion of the Meth abusing population also presents with stress and alcohol use disorders, prompting a need to understand the mechanisms underlying their comorbidities. Little is known about their possible convergent effects. Therefore, the purpose of this critical review is to identify shared mechanisms of Meth, chronic stress, and alcohol abuse that contributes to the dysfunction of vascular health and underscores the need for studies that directly address their interactions.

甲基苯丙胺 (Meth) 滥用是一个全球性问题，通常与压力和/或酒精使用障碍一起发生。无论如何，这些合并症的生物学原因和后果尚不清楚。尽管冰毒、压力和酒精滥用的机制已被单独研究并得到充分表征，但这些过程显着重叠，并且可能影响冰毒的神经和外周后果。这篇综述的重点是冰毒、压力、酗酒对心脑血管的有害影响，以及它们对大脑和外周的共病影响。重点是血脑屏障的组成及其对心脏和脉管系统的影响。特别强调自主神经系统、炎症和氧化应激是血管和血管周围健康毒性后果的常见介质。很大一部分冰毒滥​​用人群还存在压力和酒精使用障碍，因此需要了解其合并症的机制。人们对它们可能的收敛效应知之甚少。因此，本次批判性综述的目的是确定冰毒、慢性压力和酒精滥用导致血管健康功能障碍的共同机制，并强调需要进行直接解决它们相互作用的研究。