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Somatic reversion impacts myelodysplastic syndromes and acute myeloid leukemia evolution in the short telomere disorders
The Journal of Clinical Investigation ( IF 13.3 ) Pub Date : 2021 , DOI: 10.1172/jci147598 Kristen E Schratz 1, 2, 3 , Valeriya Gaysinskaya 1 , Zoe L Cosner 1 , Emily A DeBoy 1, 4 , Zhimin Xiang 1 , Laura Kasch-Semenza 4 , Liliana Florea 4, 5 , Pali D Shah 5 , Mary Armanios 1, 2, 3, 4, 6
The Journal of Clinical Investigation ( IF 13.3 ) Pub Date : 2021 , DOI: 10.1172/jci147598 Kristen E Schratz 1, 2, 3 , Valeriya Gaysinskaya 1 , Zoe L Cosner 1 , Emily A DeBoy 1, 4 , Zhimin Xiang 1 , Laura Kasch-Semenza 4 , Liliana Florea 4, 5 , Pali D Shah 5 , Mary Armanios 1, 2, 3, 4, 6
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BACKGROUND. Germline mutations in telomerase and other telomere maintenance genes manifest in the premature aging short telomere syndromes. Myelodysplastic syndromes and acute myeloid leukemia (MDS/AML) account for 75% of associated malignancies, but how these cancers overcome the inherited telomere defect is unknown.
中文翻译：
体细胞逆转影响短端粒疾病中的骨髓增生异常综合征和急性髓系白血病演变
背景。端粒酶和其他端粒维持基因的种系突变表现在过早衰老短端粒综合征中。骨髓增生异常综合征和急性髓系白血病 (MDS/AML) 占相关恶性肿瘤的 75%，但这些癌症如何克服遗传性端粒缺陷尚不清楚。
更新日期：2021-09-16
中文翻译：
体细胞逆转影响短端粒疾病中的骨髓增生异常综合征和急性髓系白血病演变
背景。端粒酶和其他端粒维持基因的种系突变表现在过早衰老短端粒综合征中。骨髓增生异常综合征和急性髓系白血病 (MDS/AML) 占相关恶性肿瘤的 75%，但这些癌症如何克服遗传性端粒缺陷尚不清楚。
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