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Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2021-08-04 , DOI: 10.1002/cbdv.202100512
Lu-Ping Chi 1, 2, 3 , Xiao-Ming Li 1, 2 , Yu-Peng Wan 1 , Yan-He Li 1, 2, 3 , Xin Li 1, 2 , Bin-Gui Wang 1, 2, 4
Affiliation  

Two new phenol derivatives, namely insphenol A (1) and acetylpeniciphenol (2), along with seven known analogs (39), were isolated from the deep-sea cold seep-derived fungus, Aspergillus insuetus SD-512. The structures of 1 and 2 were established by extensive interpretation of NMR and mass spectroscopic data. The absolute configuration of 1 was determined by the combination of coupling constant analysis and acid hydrolysis. Among the isolated compounds, insphenol A (1) represents the first example of isopentenyl phenol derivative with a unique 1-glycosylation from the species Aspergillus insuetus. The isolated new compounds were evaluated for antibacterial activities against six human or aquatic pathogens, while compound 2 exhibited inhibitory effect against Edwardsiella tarda, Vibrio alginolyticus, and V. vulnificus, with MIC values of 4, 8, and 8 μg/mL, respectively.

中文翻译:

两种来自冷渗源真菌 Aspergillus insuetus SD-512 的新型苯酚衍生物

从深海冷泉源真菌Aspergillus insuetus SD-512中分离出两种新的苯酚衍生物,即insphenol A ( 1 ) 和乙酰青霉酚 ( 2 ),以及七种已知的类似物 ( 39 ) 。12的结构是通过对 NMR 和质谱数据的广泛解释而建立的。的绝对构型1由恒定分析和酸水解联接的组合来确定。在分离的化合物中,insphenol A ( 1 ) 代表了异戊烯基苯酚衍生物的第一个例子,该衍生物具有独特的 1-糖基化猪曲霉。评估了分离的新化合物对六种人类或水生病原体的抗菌活性,而化合物2迟发性爱德华氏菌溶藻弧菌创伤弧菌具有抑制作用,MIC 值分别为 4、8 和 8 μg/mL。
更新日期:2021-08-04
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