Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512,Chemistry & Biodiversity

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Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2021-08-04 , DOI: 10.1002/cbdv.202100512
Lu-Ping Chi _{1,

2,

3} , Xiao-Ming Li _{1,

2} , Yu-Peng Wan ₁ , Yan-He Li _{1,

2,

3} , Xin Li _{1,

2} , Bin-Gui Wang _{1,

2,

4}

Affiliation

Two new phenol derivatives, namely insphenol A (1) and acetylpeniciphenol (2), along with seven known analogs (3–9), were isolated from the deep-sea cold seep-derived fungus, Aspergillus insuetus SD-512. The structures of 1 and 2 were established by extensive interpretation of NMR and mass spectroscopic data. The absolute configuration of 1 was determined by the combination of coupling constant analysis and acid hydrolysis. Among the isolated compounds, insphenol A (1) represents the first example of isopentenyl phenol derivative with a unique 1-glycosylation from the species Aspergillus insuetus. The isolated new compounds were evaluated for antibacterial activities against six human or aquatic pathogens, while compound 2 exhibited inhibitory effect against Edwardsiella tarda, Vibrio alginolyticus, and V. vulnificus, with MIC values of 4, 8, and 8 μg/mL, respectively.

中文翻译：

两种来自冷渗源真菌 Aspergillus insuetus SD-512 的新型苯酚衍生物

从深海冷泉源真菌Aspergillus insuetus SD-512中分离出两种新的苯酚衍生物，即insphenol A ( 1 ) 和乙酰青霉酚 ( 2 )，以及七种已知的类似物 ( 3 – 9 ) 。1和2的结构是通过对 NMR 和质谱数据的广泛解释而建立的。的绝对构型1由恒定分析和酸水解联接的组合来确定。在分离的化合物中，insphenol A ( 1 ) 代表了异戊烯基苯酚衍生物的第一个例子，该衍生物具有独特的 1-糖基化猪曲霉。评估了分离的新化合物对六种人类或水生病原体的抗菌活性，而化合物2对迟发性爱德华氏菌、溶藻弧菌和创伤弧菌具有抑制作用，MIC 值分别为 4、8 和 8 μg/mL。

更新日期：2021-08-04

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