Dynamic Constitutional Frameworks as Antibacterial and Antibiofilm Agents,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Dynamic Constitutional Frameworks as Antibacterial and Antibiofilm Agents
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-08-04 , DOI: 10.1002/anie.202109518
Andrei Diaconu _{1,

2} , Tom Coenye ₃ , Mihail Barboiu ₄ , Stéphane P Vincent ₁

Affiliation

Dynamic constitutional frameworks (DCFs) were synthesized and screened for biofilm inhibition or disruption. They are composed of a trialdehyde core reversibly linked to a diamine PEG connector and to a variety of neutral, anionic, or cationic heads, to generate a library of DCFs to generate multivalent dendritic architectures in the presence of Pseudomonas aeruginosa and Staphylococcus aureus. The best DCFs were always polycationic and the nature of the cationic heads significantly impact the antibiofilm activity. The best antibiofilm activity was observed for DCF3B, displaying a polyethyleneimine head. A simple inactive guanidinium functional head strongly inhibited biofilm growth when assayed as a multivalent DCF3C. Using a more advanced in vitro biofilm model of chronic wound infection, DCF3C was found significantly superior than all other DCFs. These results demonstrate the versatility and effectiveness of DCFs as low cost and efficient systems for antibiofilm disruption.

中文翻译：

作为抗菌和抗生物膜剂的动态结构框架

动态宪法框架 (DCF) 被合成并筛选生物膜抑制或破坏。它们由与二胺 PEG 连接器和各种中性、阴离子或阳离子头部可逆连接的三醛核心组成，以生成 DCF 库，从而在铜绿假单胞菌和金黄色葡萄球菌存在的情况下生成多价树突结构。最好的 DCF 总是聚阳离子，阳离子头的性质显着影响抗生物膜活性。观察到的最好的抗生物膜活性DCF3B，显示聚乙烯亚胺头。当作为多价DCF3C测定时，一个简单的非活性胍功能头强烈抑制生物膜生长. 使用更先进的慢性伤口感染体外生物膜模型，发现DCF3C明显优于所有其他 DCF。这些结果证明了 DCF 作为低成本和高效的抗生物膜破坏系统的多功能性和有效性。

更新日期：2021-09-27

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11