Introduction: Major depressive disorder (MDD) can impact the severity of allergic rhinitis (AR) and asthma (AA). Here, we evaluated the cytokine production by T-cells from AR and AA patients with or without MDD. The effect of serotonin on the in vitro T-cell response was also evaluated. Methods: The cytokines produced by activated T-cells were measured by Luminex and flow cytometry. In some cell cultures, serotonin was added. Results: MDD not only enhanced the production of Th2- and Th17-related cytokines, but also, the levels of interleukin (IL)-5 and IL-17 were directly correlated with the severity of depression and anxiety symptoms. As compared with AR, the levels of IL-17 were higher and the release of IL-10 was lower in activated T-cell cultures from AA patients, mainly those with MDD. In AA/MDD patients, the severity of anxiety symptoms and lung disease was directly correlated with Th17-like and hybrid Th2/Th17 cells, but inversely correlated with IL-10-secreting CD4⁺ T-cells. Finally, the addition of serotonin reduced the production of Th2- and Th17-related cytokines, but elevated IL-10 secretion in cell cultures from both AR and AA patients. Conclusions: Our findings suggest that not only the occurrence of MDD but also the severity of anxiety symptoms, may adversely affect the outcome of allergic reactions by favoring the production of cytokines implicated in the pathogenesis of AR and AA, a phenomenon that was attenuated by serotonin.
Int Arch Allergy Immunol

中文翻译：

---

重度抑郁症可增强过敏性鼻炎和哮喘患者的 Th2 和 Th17 细胞因子

简介：重度抑郁症 (MDD) 会影响过敏性鼻炎 (AR) 和哮喘 (AA) 的严重程度。在这里，我们评估了患有或不患有 MDD 的 AR 和 AA 患者的 T 细胞产生的细胞因子。还评估了血清素对体外 T 细胞反应的影响。方法：通过 Luminex 和流式细胞术测量活化 T 细胞产生的细胞因子。在一些细胞培养物中，添加了血清素。结果：MDD 不仅增强了 Th2 和 Th17 相关细胞因子的产生，而且白细胞介素 (IL)-5 和 IL-17 的水平与抑郁和焦虑症状的严重程度直接相关。与 AR 相比，AA 患者（主要是 MDD 患者）的活化 T 细胞培养物中 IL-17 的水平较高，IL-10 的释放较低。在 AA/MDD 患者中，焦虑症状和肺部疾病的严重程度与 Th17 样和混合 Th2/Th17 细胞直接相关，但与分泌 IL-10 的 CD4 ⁺ T 细胞呈负相关。最后，添加血清素减少了 Th2 和 Th17 相关细胞因子的产生，但增加了 AR 和 AA 患者细胞培养物中 IL-10 的分泌。结论：我们的研究结果表明，不仅 MDD 的发生，而且焦虑症状的严重程度，都可能通过促进与 AR 和 AA 发病机制有关的细胞因子的产生，从而对过敏反应的结果产生不利影响，这种现象被血清素减弱。
Int Arch 过敏免疫