### [Thomas et al. Page 1375][1] Glioblastomas (GBM) are highly invasive brain tumors that can spread rapidly throughout the brain. GBM are marked by a high rate of disease recurrence after therap. by virtue of the self-renewal capacity of glioma stem cells (GSCs), which are highly heterogeneous.

中文翻译：

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### [托马斯等人。第 1375 页][1] 胶质母细胞瘤 (GBM) 是一种侵袭性很强的脑肿瘤，可以迅速扩散到整个大脑。GBM 的特点是治疗后疾病复发率高。凭借高度异质性的神经胶质瘤干细胞 (GSC) 的自我更新能力。