In a world where information-rich methods of analysis are often sought over those with superior figures of merit, there is a constant search for ionization methods which can be applied across diverse analytical systems. The liquid sampling-atmospheric pressure glow discharge (LS-APGD) is a microplasma device which has the inherent capabilities to operate as a combined atomic and molecular (CAM) ionization source. The plasma is sustained by placement of a high voltage (~500 V, dc) onto an electrolytic solution through which the analyte is generally delivered to the discharge. Judicious choice of the solvent provides a means of obtaining atomic/elemental and/or molecular mass spectra. Presented here are the diverse modes of sample introduction and mass spectrometer platforms to which the LS-APGD has been interfaced. Likewise, representative spectra and figures of merit are presented towards elemental and isotope ratio measurements, as well as application to small organic molecules, organometallic complexes, and intact proteins. It is believed that the diversity of analytical applications and ready implementation across the entirety of mass spectrometry platforms portends a level of versatility not realized with other ionization sources.

中文翻译：

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结合原子和分子 (CAM) 电离与液体采样-大气压辉光放电微等离子体

在一个经常寻求信息丰富的分析方法而不是具有卓越品质因数的分析方法的世界中，人们一直在寻找可应用于各种分析系统的电离方法。液体采样-大气压力辉光放电 (LS-APGD) 是一种微等离子体装置，具有作为原子和分子 (CAM) 组合电离源运行的固有能力。通过将高电压（~500 V，直流）施加到电解液上来维持等离子体，分析物通常通过该电解液输送到放电。明智地选择溶剂提供了一种获得原子/元素和/或分子质谱的方法。这里介绍的是 LS-APGD 连接到的样品引入和质谱仪平台的不同模式。同样地，提供了具有代表性的光谱和品质因数，用于元素和同位素比测量，以及对有机小分子、有机金属复合物和完整蛋白质的应用。据信，分析应用的多样性和整个质谱平台的现成实施预示着其他电离源无法实现的多功能性水平。