Stimuli-Responsive Block Copolymer Micelles Based on Mussel-Inspired Metal-Coordinated Supramolecular Networks,Macromolecular Rapid Communications

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Stimuli-Responsive Block Copolymer Micelles Based on Mussel-Inspired Metal-Coordinated Supramolecular Networks
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2021-08-04 , DOI: 10.1002/marc.202100312
Ritabrata Ganguly ₁ , Pabitra Saha _{2,

3} , Sovan Lal Banerjee ₁ , Andrij Pich _{2,

3,

4} , Nikhil K Singha _{1,

5}

Affiliation

Amphiphilic diblock copolymers containing dopamine and zwitterions are synthesized via the RAFT polymerization method, which undergo temperature-mediated micellization in aqueous media. The presence of catechol moiety in dopamine is exploited to form pH-responsive cross-links with ferric ions (Fe³⁺) at different pH value. Herein, a comprehensive study of the effect of pH as well as temperature on the size and solution behavior of these cross-linked micelles is presented. These micelles cross-linked via metal–catechol coordination bonds can have several important biomedical applications such as degradable scaffolds for payload delivery.

中文翻译：

基于贻贝启发金属配位超分子网络的刺激响应嵌段共聚物胶束

含有多巴胺和两性离子的两亲性二嵌段共聚物是通过 RAFT 聚合方法合成的，其在水性介质中进行温度介导的胶束化。利用多巴胺中儿茶酚部分的存在与不同 pH 值的三价铁离子 (Fe ³⁺ )形成 pH 响应性交联。在此，全面研究了 pH 值和温度对这些交联胶束的尺寸和溶液行为的影响。这些通过金属-邻苯二酚配位键交联的胶束可以具有多种重要的生物医学应用，例如用于有效载荷传递的可降解支架。

更新日期：2021-09-07

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