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A Disposable Printed Liquid Gate Graphene Field Effect Transistor for a Salivary Cortisol Test
ACS Sensors ( IF 8.2 ) Pub Date : 2021-08-03 , DOI: 10.1021/acssensors.1c00949 Rong Zhang 1 , Yunfang Jia 1
ACS Sensors ( IF 8.2 ) Pub Date : 2021-08-03 , DOI: 10.1021/acssensors.1c00949 Rong Zhang 1 , Yunfang Jia 1
Affiliation
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Circadian rhythm of salivary cortisol is of clinical significance, tracking salivary cortisol in domicile is welcomed by both doctor and patient, due to its merits of noninvasion, ease of sampling, and free-of-stress response. Here, we present a portable salivary cortisol test setup based on a liquid gate graphene field effect transistor (Lg-GFET) for the first time. In this work, the Lg-GFET was prepared by the printing technology and exploited as a sensitive material. In the procedures of device preparation, the modified liquid exfoliation method and direct-ink-write technology were utilized for synthesizing the graphene ink and printing Lg-GFETs; then, the as-prepared Lg-GFETs were decorated and functionalized by tetrakis(4-carboxyphenyl) porphyrin and the cortisol aptamer, successively. Their sensitivity, selectivity, and robustness are seriously examined. The test results indicate that the sensors have good linear sensitivities over a seven-log analyte concentration range (0.01 to 104 nM) and the anti-interference ability to distinguish from the substancess with similar chemical structures. Moreover, the conceptual application for tracking circadian rhythm was carried out successfully. Conclusively, the proposed flexible Lg-GFET-based salivary cortisol detection platform can satisfy the requirements of the salivary cortisol’s assay for instant detection. Additionally, it also provides an alternative solution for developing similar household medical appliances.
中文翻译：
用于唾液皮质醇测试的一次性印刷液栅石墨烯场效应晶体管
唾液皮质醇昼夜节律具有临床意义，在住所追踪唾液皮质醇具有无侵袭性、易于采样、无应激反应等优点，受到医患双方的欢迎。在这里，我们首次提出了一种基于液栅石墨烯场效应晶体管 (Lg-GFET) 的便携式唾液皮质醇测试装置。在这项工作中，Lg-GFET 是通过印刷技术制备的，并被用作敏感材料。在器件制备过程中，利用改进的液体剥离法和直接墨水写入技术合成石墨烯墨水和印刷Lg-GFET；然后，所制备的 Lg-GFET 依次被四（4-羧基苯基）卟啉和皮质醇适体修饰和功能化。它们的灵敏度、选择性、和稳健性被认真检查。测试结果表明，传感器在 7 个对数分析物浓度范围内（0.01 至 104 nM）和抗干扰能力，以区别化学结构相似的物质。此外，跟踪昼夜节律的概念应用也成功进行。最后，所提出的灵活的基于 Lg-GFET 的唾液皮质醇检测平台可以满足唾液皮质醇检测的即时检测要求。此外，它还为开发类似的家用医疗器械提供了一种替代解决方案。
更新日期：2021-08-27
中文翻译：
用于唾液皮质醇测试的一次性印刷液栅石墨烯场效应晶体管
唾液皮质醇昼夜节律具有临床意义，在住所追踪唾液皮质醇具有无侵袭性、易于采样、无应激反应等优点，受到医患双方的欢迎。在这里，我们首次提出了一种基于液栅石墨烯场效应晶体管 (Lg-GFET) 的便携式唾液皮质醇测试装置。在这项工作中，Lg-GFET 是通过印刷技术制备的，并被用作敏感材料。在器件制备过程中，利用改进的液体剥离法和直接墨水写入技术合成石墨烯墨水和印刷Lg-GFET；然后，所制备的 Lg-GFET 依次被四（4-羧基苯基）卟啉和皮质醇适体修饰和功能化。它们的灵敏度、选择性、和稳健性被认真检查。测试结果表明，传感器在 7 个对数分析物浓度范围内（0.01 至 104 nM）和抗干扰能力，以区别化学结构相似的物质。此外，跟踪昼夜节律的概念应用也成功进行。最后，所提出的灵活的基于 Lg-GFET 的唾液皮质醇检测平台可以满足唾液皮质醇检测的即时检测要求。此外，它还为开发类似的家用医疗器械提供了一种替代解决方案。
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