Dielectrophoresis (DEP) is a technique to manipulate trajectories of polarisable particles in nonuniform electric fields by utilizing unique dielectric properties. The manipulation of a cell using DEP has been demonstrated in various modes, thereby indicating potential applications in the biomedical field. In this review, recent DEP applications in the biomedical field are discussed. This review is intended to highlight research work that shows significant approach related to DEP application in biomedical field reported between 2016 and 2020. First, single-shell model and multiple-shell model of cells are introduced. Current device structures and recently introduced electrode patterns for DEP applications are discussed. Second, the biomedical uses of DEP in liquid biopsies, stem cell-based therapies, and diagnosis of infectious diseases due to bacteria and viruses are presented. Finally, the challenges in DEP research are discussed, and the reported solutions are explained. DEP's potential research directions are mentioned.

中文翻译：

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介电泳在生物医学领域的应用和生物医学技术的未来展望

介电电泳 (DEP) 是一种利用独特的介电特性在非均匀电场中操纵可极化粒子轨迹的技术。使用 DEP 对细胞的操作已在各种模式下得到证明，从而表明在生物医学领域的潜在应用。在这篇综述中，讨论了最近 DEP 在生物医学领域的应用。本综述旨在突出显示 2016 年至 2020 年间报告的与 DEP 在生物医学领域应用相关的重要方法的研究工作。首先，介绍了细胞的单壳模型和多壳模型。讨论了当前的器件结构和最近引入的用于 DEP 应用的电极图案。其次，DEP 在液体活检、基于干细胞的疗法中的生物医学用途、并介绍了由细菌和病毒引起的传染病的诊断。最后，讨论了 DEP 研究中的挑战，并解释了报告的解决方案。提到了 DEP 的潜在研究方向。