Tendons are cable-like connective tissues that transfer both active and passive forces generated by skeletal muscle to bone. In the mature skeleton, the tendon-bone enthesis is an interfacial zone of transitional tissue located between two mechanically dissimilar tissues: compliant, fibrous tendon to rigid, dense mineralized bone. In this review, we focus on emerging areas in enthesis development related to its structure, function, and mechanobiology, as well as highlight established and emerging signaling pathways and physiological processes that influence the formation and adaptation of this important transitional tissue.

中文翻译：

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腱骨附着点的生长和机械生物学

肌腱是电缆状结缔组织，可将骨骼肌产生的主动力和被动力传递到骨骼。在成熟的骨骼中，肌腱-骨附着点是过渡组织的界面区域，位于两个机械上不同的组织之间：顺从的纤维肌腱到坚硬、致密的矿化骨。在这篇综述中，我们重点关注与其结构、功能和力学生物学相关的附着点发展的新兴领域，并强调影响这一重要过渡组织形成和适应的已建立和新兴信号通路和生理过程。