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The Combined Use of a Non-Invasive Skin-Stretching Device and the Negative-Pressure Wound Therapy Technique in the Treatment of Postoperative Diabetic Foot
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy ( IF 2.8 ) Pub Date : 2021-08-05 , DOI: 10.2147/dmso.s322757 Liangchen Wang 1 , Chenrui Wang 1 , Hongmei Chen 1 , Ying Chen 1 , Juan Li 1 , Li Xiao 1 , Di Zhu 1 , Caizhe Yang 1
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy ( IF 2.8 ) Pub Date : 2021-08-05 , DOI: 10.2147/dmso.s322757 Liangchen Wang 1 , Chenrui Wang 1 , Hongmei Chen 1 , Ying Chen 1 , Juan Li 1 , Li Xiao 1 , Di Zhu 1 , Caizhe Yang 1
Affiliation
Objective: The present study explored the effectiveness of using a non-invasive skin-stretching device (NSSD) combined with negative-pressure wound therapy (NPWT) for the postoperative wound repair of diabetic foot (DF) gangrene.
Methods: The treatment group in this study involved 42 patients with Wagner grade 3– 4 DF and undergone concomitant toe amputation or debridement, who were given NPWT combined with the use of a NSSD. The control group comprised 42 patients with similar trauma areas (± 20%) that were matched at a ratio of 1:1. Following surgery, these patients received NPWT combined with the use of conventional dressings. A comparison was made of the postoperative wound healing rates and wound healing times of the two groups, with Kaplan–Meier survival analysis being used to compare the healing rate over time.
Results: The three-month wound healing rate was higher in the treatment group than in the control group (38 of 42 [90.5%] vs 25 of 42 [59.5%], p = 0.002), and the wound healing time was shorter in the treatment group (44 days [95% CI 40.0– 48.0]) than that in the control group (76 days [95% CI 63.0– 89.0], p = 0.000). Taking the end of the final NPWT as the starting point, the comparison of wound healing time revealed that this period was shorter in the treatment group than that in the control group and the difference was statistically significant (11 days [95% CI 9.0– 13.0] vs 42 days [95% CI 23.0–ND], p = 0.000).
Conclusion: The use of the NPWT technique combined with a NSSD can shorten the wound healing time and improve the wound healing rate of DF gangrene patients during the postoperative wound repair period.
Keywords: diabetic foot, negative-pressure wound therapy, wound healing, skin-stretching device
中文翻译：
无创皮肤拉伸装置与负压创面治疗技术在糖尿病足术后治疗中的联合应用
目的：本研究探讨了使用无创皮肤拉伸装置（NSSD）联合负压伤口治疗（NPWT）对糖尿病足（DF）坏疽术后伤口修复的有效性。
方法：本研究中的治疗组包括 42 名 Wagner 3-4 级DF患者并进行了伴随的脚趾截肢或清创，他们被给予 NPWT 并结合使用 NSSD。对照组包括 42 名具有相似创伤区域 (± 20%) 的患者，他们以 1:1 的比例匹配。手术后，这些患者接受了 NPWT 并结合使用传统敷料。比较两组术后创面愈合率和创面愈合时间，采用Kaplan-Meier生存分析比较愈合率随时间变化。
结果：治疗组 3 个月的伤口愈合率高于对照组（42 人中的 38 人 [90.5%] vs 42 人中的 25 人 [59.5%]，p = 0.002），并且治疗中的伤口愈合时间更短组（44 天 [95% CI 40.0–48.0]）比对照组（76 天 [95% CI 63.0–89.0]，p = 0.000）。以最终NPWT结束为起点，比较创面愈合时间，治疗组该时间短于对照组，差异有统计学意义（11天[95% CI 9.0-13.0 ] 与 42 天 [95% CI 23.0–ND], p = 0.000)。
结论：采用NPWT技术联合NSSD可缩短DF创面愈合时间，提高创面愈合率。坏疽患者在术后伤口修复期间。
关键词：糖尿病足 负压创面疗法 创面愈合 皮肤拉伸装置
更新日期：2021-08-04
Methods: The treatment group in this study involved 42 patients with Wagner grade 3– 4 DF and undergone concomitant toe amputation or debridement, who were given NPWT combined with the use of a NSSD. The control group comprised 42 patients with similar trauma areas (± 20%) that were matched at a ratio of 1:1. Following surgery, these patients received NPWT combined with the use of conventional dressings. A comparison was made of the postoperative wound healing rates and wound healing times of the two groups, with Kaplan–Meier survival analysis being used to compare the healing rate over time.
Results: The three-month wound healing rate was higher in the treatment group than in the control group (38 of 42 [90.5%] vs 25 of 42 [59.5%], p = 0.002), and the wound healing time was shorter in the treatment group (44 days [95% CI 40.0– 48.0]) than that in the control group (76 days [95% CI 63.0– 89.0], p = 0.000). Taking the end of the final NPWT as the starting point, the comparison of wound healing time revealed that this period was shorter in the treatment group than that in the control group and the difference was statistically significant (11 days [95% CI 9.0– 13.0] vs 42 days [95% CI 23.0–ND], p = 0.000).
Conclusion: The use of the NPWT technique combined with a NSSD can shorten the wound healing time and improve the wound healing rate of DF gangrene patients during the postoperative wound repair period.
Keywords: diabetic foot, negative-pressure wound therapy, wound healing, skin-stretching device
中文翻译：
无创皮肤拉伸装置与负压创面治疗技术在糖尿病足术后治疗中的联合应用
目的：本研究探讨了使用无创皮肤拉伸装置（NSSD）联合负压伤口治疗（NPWT）对糖尿病足（DF）坏疽术后伤口修复的有效性。
方法：本研究中的治疗组包括 42 名 Wagner 3-4 级DF患者并进行了伴随的脚趾截肢或清创，他们被给予 NPWT 并结合使用 NSSD。对照组包括 42 名具有相似创伤区域 (± 20%) 的患者，他们以 1:1 的比例匹配。手术后，这些患者接受了 NPWT 并结合使用传统敷料。比较两组术后创面愈合率和创面愈合时间，采用Kaplan-Meier生存分析比较愈合率随时间变化。
结果：治疗组 3 个月的伤口愈合率高于对照组（42 人中的 38 人 [90.5%] vs 42 人中的 25 人 [59.5%]，p = 0.002），并且治疗中的伤口愈合时间更短组（44 天 [95% CI 40.0–48.0]）比对照组（76 天 [95% CI 63.0–89.0]，p = 0.000）。以最终NPWT结束为起点，比较创面愈合时间，治疗组该时间短于对照组，差异有统计学意义（11天[95% CI 9.0-13.0 ] 与 42 天 [95% CI 23.0–ND], p = 0.000)。
结论：采用NPWT技术联合NSSD可缩短DF创面愈合时间，提高创面愈合率。坏疽患者在术后伤口修复期间。
关键词：糖尿病足 负压创面疗法 创面愈合 皮肤拉伸装置
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